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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029838.2 RefSeqGene
- Range
-
22202..45508
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001207017.1 → NP_001193946.1 smoothelin isoform d
See identical proteins and their annotated locations for NP_001193946.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) encodes the longest isoform (d).
- Source sequence(s)
-
AK304084, BC034237, Z49989
- Consensus CDS
-
CCDS74845.1
- UniProtKB/TrEMBL
- A0A087X1R1, B4E229
- Related
- ENSP00000484398.1, ENST00000619644.5
- Conserved Domains (2) summary
-
- cd00014
Location:887 → 991
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam12510
Location:655 → 704
- Smoothelin; Smoothelin cytoskeleton protein
-
NM_001207018.2 → NP_001193947.1 smoothelin isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks two exons from the 5' end, has an alternate 5' exon, lacks an in-frame exon in the middle region and has an additional exon in the 3' region, compared to variant 4. The resulting isoform (e) has distinct N- and C-termini, and lacks an internal segment, compared to isoform d.
- Source sequence(s)
-
AK295418, BC034237, Z49989
- Consensus CDS
-
CCDS74846.1
- UniProtKB/TrEMBL
- A0A087WVP4, B4DI56
- Related
- ENSP00000479578.1, ENST00000612341.4
- Conserved Domains (2) summary
-
- cd00014
Location:858 → 958
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam12510
Location:626 → 675
- Smoothelin; Smoothelin cytoskeleton protein
-
NM_001382638.1 → NP_001369567.1 smoothelin isoform b
Status: REVIEWED
- Source sequence(s)
-
AC005005
- Consensus CDS
-
CCDS13888.1
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:800 → 911
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_001382639.1 → NP_001369568.1 smoothelin isoform b
Status: REVIEWED
- Source sequence(s)
-
AC005005
- Consensus CDS
-
CCDS13888.1
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:800 → 911
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_001382640.1 → NP_001369569.1 smoothelin isoform b
Status: REVIEWED
- Source sequence(s)
-
AC005005
- Consensus CDS
-
CCDS13888.1
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:800 → 911
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_001382641.1 → NP_001369570.1 smoothelin isoform b
Status: REVIEWED
- Source sequence(s)
-
AC005005
- Consensus CDS
-
CCDS13888.1
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:800 → 911
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_001382642.1 → NP_001369571.1 smoothelin isoform f
Status: REVIEWED
- Source sequence(s)
-
AC005005
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- pfam12510
Location:664 → 713
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:894 → 1005
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_001382643.1 → NP_001369572.1 smoothelin isoform g
Status: REVIEWED
- Source sequence(s)
-
AC005005
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- pfam12510
Location:624 → 673
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:854 → 965
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_001382644.1 → NP_001369573.1 smoothelin isoform g
Status: REVIEWED
- Source sequence(s)
-
AC005005
- UniProtKB/TrEMBL
-
C9JYU8
- Related
- ENSP00000401341.2, ENST00000440425.6
- Conserved Domains (2) summary
-
- pfam12510
Location:624 → 673
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:854 → 965
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_001382645.1 → NP_001369574.1 smoothelin isoform h
Status: REVIEWED
- Source sequence(s)
-
AC005005
- UniProtKB/TrEMBL
-
B3KY41
-
NM_001382646.1 → NP_001369575.1 smoothelin isoform i
Status: REVIEWED
- Source sequence(s)
-
AC005005
- UniProtKB/TrEMBL
-
B4E229
- Conserved Domains (1) summary
-
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
-
NM_001382647.1 → NP_001369576.1 smoothelin isoform j
Status: REVIEWED
- Source sequence(s)
-
AC005005
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:724 → 835
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_001382648.1 → NP_001369577.1 smoothelin isoform k
Status: REVIEWED
- Source sequence(s)
-
AC005005
- Conserved Domains (2) summary
-
- pfam12510
Location:228 → 277
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:458 → 569
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_006932.5 → NP_008863.3 smoothelin isoform c
See identical proteins and their annotated locations for NP_008863.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) has an alternate 5' exon, which results in a downstream AUG start codon, and lacks an in-frame exon in the middle region, compared to variant 4. The resulting isoform (c, also referred to as L1, B and c1) is shorter at the N-terminus and lacks an internal segment, compared to isoform d. This isoform is highly expressed in all vascularized organs and represents a vascular smooth muscle-specific form. This transcript also includes an alternate downstream translation initiation site, which results in the smoothelin-A product, a visceral smooth muscle-specific form.
- Source sequence(s)
-
AJ010306, BC034237, DC342566, Z49989
- Consensus CDS
-
CCDS13886.1
- UniProtKB/Swiss-Prot
- O00569, O95769, O95937, P53814, Q8N4H8, Q8WWW1, Q8WWW2, Q9P1S8, Q9UIT1, Q9UIT2
- UniProtKB/TrEMBL
-
C9JYU8
- Related
- ENSP00000328635.5, ENST00000347557.6
- Conserved Domains (2) summary
-
- cd00014
Location:802 → 906
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
-
NM_134269.3 → NP_599031.1 smoothelin isoform b
See identical proteins and their annotated locations for NP_599031.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) has an alternate 5' exon, which results in a downstream AUG start codon, lacks an in-frame exon in the middle region and has an additional exon in the 3' region, compared to variant 4. The resulting isoform (b, also referred to as L2 and B2) is shorter at the N-terminus, lacks a segment in the middle region and has a slightly shorter and distinct C-terminus, compared to isoform d.
- Source sequence(s)
-
BC034237, DC342566, Z49989
- Consensus CDS
-
CCDS13888.1
- UniProtKB/TrEMBL
-
C9JYU8
- Related
- ENSP00000329532.7, ENST00000333137.12
- Conserved Domains (2) summary
-
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
- cd21259
Location:800 → 911
- CH_SMTNB; calponin homology (CH) domain found in smoothelin-B and similar proteins
-
NM_134270.3 → NP_599032.2 smoothelin isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) has an alternate 5' exon, which results in a downstream AUG start codon, lacks an in-frame exon in the middle region and has an additional in-frame exon in the 3' region, compared to variant 4. The resulting isoform (a, also referred to as B3) is shorter at the N-terminus, lacks a segment in the middle region and has an additional segment in the C-terminal region, compared to isoform d.
- Source sequence(s)
-
BC034237, DC342566, Z49989
- Consensus CDS
-
CCDS13887.1
- UniProtKB/TrEMBL
-
C9JYU8
- Related
- ENSP00000351593.1, ENST00000358743.5
- Conserved Domains (2) summary
-
- cd00014
Location:802 → 929
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam12510
Location:570 → 619
- Smoothelin; Smoothelin cytoskeleton protein
RNA
-
NR_168472.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC005005
-
NR_168473.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC005005
-
NR_168474.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC005005
-
NR_168475.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC005005
- Related
-
ENST00000489337.5
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000022.11 Reference GRCh38.p14 Primary Assembly
- Range
-
31064118..31104624
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017028913.2 → XP_016884402.1 smoothelin isoform X1
- UniProtKB/TrEMBL
- A0A087X1R1, B4E229
- Conserved Domains (2) summary
-
- cd00014
Location:887 → 991
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam12510
Location:655 → 704
- Smoothelin; Smoothelin cytoskeleton protein
-
XM_017028917.2 → XP_016884406.1 smoothelin isoform X5
- UniProtKB/TrEMBL
-
B4E229
-
XM_011530336.3 → XP_011528638.1 smoothelin isoform X6
- UniProtKB/TrEMBL
-
B4E229
- Conserved Domains (2) summary
-
- cd00014
Location:811 → 915
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam12510
Location:655 → 704
- Smoothelin; Smoothelin cytoskeleton protein
-
XM_017028914.2 → XP_016884403.1 smoothelin isoform X3
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- cd00014
Location:856 → 960
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam12510
Location:624 → 673
- Smoothelin; Smoothelin cytoskeleton protein
-
XM_011530338.3 → XP_011528640.1 smoothelin isoform X10
- UniProtKB/TrEMBL
-
C9JYU8
- Conserved Domains (2) summary
-
- cd00014
Location:780 → 884
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam12510
Location:624 → 673
- Smoothelin; Smoothelin cytoskeleton protein
-
XM_047441466.1 → XP_047297422.1 smoothelin isoform X2
- UniProtKB/TrEMBL
-
C9JYU8
-
XM_047441467.1 → XP_047297423.1 smoothelin isoform X4
- UniProtKB/TrEMBL
-
B4E229
-
XM_047441469.1 → XP_047297425.1 smoothelin isoform X8
- UniProtKB/TrEMBL
-
C9JYU8
-
XM_047441468.1 → XP_047297424.1 smoothelin isoform X7
- UniProtKB/TrEMBL
-
B4E229
-
XM_047441470.1 → XP_047297426.1 smoothelin isoform X11
- UniProtKB/TrEMBL
-
C9JYU8
-
XM_017028918.2 → XP_016884407.1 smoothelin isoform X9
- UniProtKB/TrEMBL
-
B3KUD6
-
XM_047441471.1 → XP_047297427.1 smoothelin isoform X13
- UniProtKB/TrEMBL
-
B3KY54
-
XM_011530339.3 → XP_011528641.1 smoothelin isoform X12
- Conserved Domains (1) summary
-
- pfam12510
Location:655 → 704
- Smoothelin; Smoothelin cytoskeleton protein
Alternate T2T-CHM13v2.0
Genomic
-
NC_060946.1 Alternate T2T-CHM13v2.0
- Range
-
31527653..31568123
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054325853.1 → XP_054181828.1 smoothelin isoform X1
- UniProtKB/TrEMBL
-
B4E229
-
XM_054325857.1 → XP_054181832.1 smoothelin isoform X5
- UniProtKB/TrEMBL
-
B4E229
-
XM_054325858.1 → XP_054181833.1 smoothelin isoform X6
- UniProtKB/TrEMBL
-
B4E229
-
XM_054325855.1 → XP_054181830.1 smoothelin isoform X3
- UniProtKB/TrEMBL
-
C9JYU8
-
XM_054325862.1 → XP_054181837.1 smoothelin isoform X10
- UniProtKB/TrEMBL
-
C9JYU8
-
XM_054325854.1 → XP_054181829.1 smoothelin isoform X2
- UniProtKB/TrEMBL
-
C9JYU8
-
XM_054325856.1 → XP_054181831.1 smoothelin isoform X4
- UniProtKB/TrEMBL
-
B4E229
-
XM_054325860.1 → XP_054181835.1 smoothelin isoform X8
- UniProtKB/TrEMBL
-
C9JYU8
-
XM_054325859.1 → XP_054181834.1 smoothelin isoform X7
- UniProtKB/TrEMBL
-
B4E229
-
XM_054325863.1 → XP_054181838.1 smoothelin isoform X11
- UniProtKB/TrEMBL
-
C9JYU8
-
XM_054325861.1 → XP_054181836.1 smoothelin isoform X9
- UniProtKB/TrEMBL
-
B3KUD6
-
XM_054325866.1 → XP_054181841.1 smoothelin isoform X13
- UniProtKB/TrEMBL
-
B3KY54
-
XM_054325865.1 → XP_054181840.1 smoothelin isoform X12
-
XM_054325864.1 → XP_054181839.1 smoothelin isoform X14
- UniProtKB/TrEMBL
-
B3KY41