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    Acsl1 acyl-CoA synthetase long-chain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 14081, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acsl1provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 1provided by MGI
    Primary source
    MGI:MGI:102797
    See related
    Ensembl:ENSMUSG00000018796 AllianceGenome:MGI:102797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acs; Acas; FACS; Acas1; Facl2; LACS1; LACS 1
    Summary
    The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in liver E18 (RPKM 94.6), subcutaneous fat pad adult (RPKM 79.5) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Acsl1 in Genome Data Viewer
    Location:
    8 B1.1; 8 26.36 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46924214..46989088)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46471037..46536051)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:47396583-47396884 Neighboring gene predicted gene, 39168 Neighboring gene STARR-seq mESC enhancer starr_21381 Neighboring gene predicted gene, 30931 Neighboring gene STARR-seq mESC enhancer starr_21383 Neighboring gene STARR-seq mESC enhancer starr_21384 Neighboring gene STARR-positive B cell enhancer ABC_E2261 Neighboring gene STARR-positive B cell enhancer ABC_E6635 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:47637172-47637355 Neighboring gene centromere protein U Neighboring gene primase and polymerase (DNA-directed) Neighboring gene predicted gene 45607

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables arachidonate-CoA ligase activity  
    enables arachidonate-CoA ligase activity  
    enables arachidonate-CoA ligase activity  
    enables long-chain fatty acid-CoA ligase activity  
    enables long-chain fatty acid-CoA ligase activity  
    enables oleoyl-CoA ligase activity  
    enables oleoyl-CoA ligase activity  
    enables phytanate-CoA ligase activity  
    enables phytanate-CoA ligase activity  
    enables pristanate-CoA ligase activity  
    enables protein serine/threonine kinase activator activity PubMed 
    enables protein serine/threonine kinase activator activity PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adiponectin-activated signaling pathway PubMed 
    involved_in fatty acid metabolic process  
    involved_in fatty acid transport  
    involved_in lipid biosynthetic process  
    involved_in long-chain fatty acid import into cell  
    involved_in long-chain fatty acid import into cell  
    involved_in long-chain fatty acid metabolic process  
    involved_in long-chain fatty acid metabolic process  
    involved_in long-chain fatty acid metabolic process  
    involved_in long-chain fatty-acyl-CoA biosynthetic process  
    involved_in long-chain fatty-acyl-CoA biosynthetic process  
    involved_in long-chain fatty-acyl-CoA biosynthetic process  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of long-chain fatty acid import across plasma membrane  
    involved_in positive regulation of long-chain fatty acid import across plasma membrane  
    involved_in response to nutrient  
    involved_in response to oleic acid  
    involved_in response to organic cyclic compound  
    involved_in triglyceride biosynthetic process  
    involved_in triglyceride biosynthetic process  
    involved_in very long-chain fatty acid metabolic process  
    involved_in very long-chain fatty acid metabolic process  
    involved_in very long-chain fatty acid metabolic process  
    involved_in xenobiotic catabolic process  
    involved_in xenobiotic catabolic process  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in peroxisomal membrane  
    located_in peroxisomal membrane  

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 1
    Names
    acetate-CoA ligase
    acetyl-CoA synthetase
    acetyl-Coenzyme A synthetase 1 (ADP forming)
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 2
    long-chain acyl-CoA synthetase 1
    phytanate--CoA ligase
    NP_001289092.1
    NP_001411721.1
    NP_001411722.1
    NP_001411723.1
    NP_032007.2
    XP_006509325.2
    XP_006509328.1
    XP_006509329.1
    XP_017168052.1
    XP_030099145.1
    XP_036009645.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302163.2NP_001289092.1  long-chain-fatty-acid--CoA ligase 1 isoform 1

      See identical proteins and their annotated locations for NP_001289092.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AC119267, AC138367
      Consensus CDS
      CCDS22291.1
      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Related
      ENSMUSP00000106001.2, ENSMUST00000110372.9
      Conserved Domains (1) summary
      cd05927
      Location:117695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. NM_001424792.1NP_001411721.1  long-chain-fatty-acid--CoA ligase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC119267, AC138367
      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
    3. NM_001424793.1NP_001411722.1  long-chain-fatty-acid--CoA ligase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119267, AC138367
    4. NM_001424794.1NP_001411723.1  long-chain-fatty-acid--CoA ligase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119267, AC138367
    5. NM_007981.5NP_032007.2  long-chain-fatty-acid--CoA ligase 1 isoform 1

      See identical proteins and their annotated locations for NP_032007.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AC119267, AC138367
      Consensus CDS
      CCDS22291.1
      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Related
      ENSMUSP00000034046.6, ENSMUST00000034046.13
      Conserved Domains (1) summary
      cd05927
      Location:117695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      46924214..46989088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312563.3XP_017168052.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Conserved Domains (1) summary
      cd05927
      Location:117695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. XM_006509266.4XP_006509329.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509329.1

      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Conserved Domains (1) summary
      cd05927
      Location:117695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. XM_006509265.4XP_006509328.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509328.1

      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Conserved Domains (1) summary
      cd05927
      Location:117695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    4. XM_030243285.2XP_030099145.1  long-chain-fatty-acid--CoA ligase 1 isoform X3

      UniProtKB/TrEMBL
      D3Z041
      Related
      ENSMUSP00000106000.2, ENSMUST00000110371.8
      Conserved Domains (1) summary
      cd05927
      Location:117695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    5. XM_006509262.4XP_006509325.2  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509325.2

      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Conserved Domains (1) summary
      cd05927
      Location:117695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    6. XM_036153752.1XP_036009645.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

      Conserved Domains (1) summary
      cl17068
      Location:1370
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RNA

    1. XR_004934769.1 RNA Sequence

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