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    Klhdc2 kelch domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 69554, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klhdc2provided by MGI
    Official Full Name
    kelch domain containing 2provided by MGI
    Primary source
    MGI:MGI:1916804
    See related
    Ensembl:ENSMUSG00000020978 AllianceGenome:MGI:1916804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LCP; HCLP-1; D12Ertd522e; 2310022K15Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nuclear body and nuclear membrane. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human KLHDC2 (kelch domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 57.4), CNS E18 (RPKM 56.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Klhdc2 in Genome Data Viewer
    Location:
    12 C2; 12 28.77 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69343455..69357461)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69296681..69310687)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330151L19 gene Neighboring gene dynein, axonemal assembly factor 2 Neighboring gene STARR-seq mESC enhancer starr_32361 Neighboring gene polymerase (DNA directed), epsilon 2 (p59 subunit) Neighboring gene STARR-positive B cell enhancer ABC_E10753 Neighboring gene kelch domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32363 Neighboring gene nuclear export mediator factor Neighboring gene STARR-seq mESC enhancer starr_32364 Neighboring gene STARR-positive B cell enhancer ABC_E10754 Neighboring gene STARR-positive B cell enhancer ABC_E7139 Neighboring gene STARR-positive B cell enhancer ABC_E600 Neighboring gene 7S RNA 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex  
    part_of Cul2-RING ubiquitin ligase complex  
    located_in nuclear body  
    located_in nuclear body  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus  

    General protein information

    Preferred Names
    kelch domain-containing protein 2
    Names
    endothelial differentiation inhibitory protein TNG

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027117.3NP_081393.2  kelch domain-containing protein 2

      See identical proteins and their annotated locations for NP_081393.2

      Status: VALIDATED

      Source sequence(s)
      AC099934, AK009481
      Consensus CDS
      CCDS25950.1
      UniProtKB/Swiss-Prot
      E9QKN6, Q4G5Y1, Q99JY2, Q9D784
      Related
      ENSMUSP00000021362.5, ENSMUST00000021362.5
      Conserved Domains (3) summary
      PLN02193
      Location:29296
      PLN02193; nitrile-specifier protein
      sd00038
      Location:218265
      Kelch; KELCH repeat [structural motif]
      pfam13415
      Location:279326
      Kelch_3; Galactose oxidase, central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69343455..69357461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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