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    Tunar Tcl1 upstream neural differentiation associated RNA [ Mus musculus (house mouse) ]

    Gene ID: 69952, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tunarprovided by MGI
    Official Full Name
    Tcl1 upstream neural differentiation associated RNAprovided by MGI
    Primary source
    MGI:MGI:1917202
    See related
    Ensembl:ENSMUSG00000097929 AllianceGenome:MGI:1917202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BNLN; Tuna; pTUNAR; Mi-Lnc78; 2810011L19Rik
    Summary
    Enables ATPase binding activity. Involved in negative regulation of neuron differentiation; neuron projection morphogenesis; and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including neuron fate commitment; positive regulation of mitotic cell cycle; and positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; eye; pancreas; and reproductive system. Orthologous to human TUNAR (TCL1 upstream neural differentiation-associated RNA). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 7.4), CNS E18 (RPKM 4.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tunar in Genome Data Viewer
    Location:
    12 E; 12 55.45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105303087..105350191)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105336594..105383932)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33171 Neighboring gene predicted gene, 53762 Neighboring gene predicted gene, 53763 Neighboring gene STARR-seq mESC enhancer starr_33174 Neighboring gene STARR-seq mESC enhancer starr_33176 Neighboring gene STARR-seq mESC enhancer starr_33177 Neighboring gene predicted gene 2721 Neighboring gene RIKEN cDNA D430019H16 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response. Simmers MD, et al. Front Cell Dev Biol, 2023. PMID 37325564, Free PMC Article
    2. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Senís E, et al. Front Cell Dev Biol, 2021. PMID 35036403, Free PMC Article
    3. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Morán I, et al. Cell Metab, 2012 Oct 3. PMID 23040067, Free PMC Article
    4. An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Lin N, et al. Mol Cell, 2014 Mar 20. PMID 24530304, Free PMC Article
    5. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein TUNAR
    Names
    beta cell and neural cell-regulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416144.1 → NP_001403073.1  protein TUNAR

      Status: VALIDATED

      Source sequence(s)
      AC122013

    2. NM_001416145.1 → NP_001403074.1  protein TUNAR

      Status: VALIDATED

      Source sequence(s)
      AC122013

    RNA

    1. NR_183401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122013
      Related
      ENSMUST00000180503.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      105303087..105350191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_045047.1: Suppressed sequence

      Description
      NR_045047.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

    2. NR_125773.1: Suppressed sequence

      Description
      NR_125773.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1B0GQX2.2 GenPept UniProtKB/Swiss-Prot:A0A1B0GQX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.