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    Gata2 GATA binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14461, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gata2provided by MGI
    Official Full Name
    GATA binding protein 2provided by MGI
    Primary source
    MGI:MGI:95662
    See related
    Ensembl:ENSMUSG00000015053 AllianceGenome:MGI:95662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gata-2
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Acts upstream of or within several processes, including negative regulation of cell differentiation; neuron differentiation; and regulation of myeloid cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in acute myeloid leukemia; depressive disorder; immunodeficiency 21; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 56.2), adrenal adult (RPKM 25.3) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gata2 in Genome Data Viewer
    Location:
    6 D1; 6 39.2 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88170873..88184014)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88193891..88207032)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53293 Neighboring gene Gata2R1 erythroid cis-regulatory module Neighboring gene stem and progenitor enriched required for hematopoietic differentiation Neighboring gene predicted gene, 38856 Neighboring gene Gata2R7 and Gata2R8 erythroid cis-regulatory modules Neighboring gene Gata2R5 erythroid cis-regulatory module Neighboring gene Gata2R6 erythroid cis-regulatory module Neighboring gene DnaJ heat shock protein family (Hsp40) member B8 Neighboring gene predicted gene, 57776 Neighboring gene eukaryotic elongation factor, selenocysteine-tRNA-specific

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129339

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within GABAergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell fate determination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eosinophil fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eosinophil fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glandular epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glandular epithelial cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuroendocrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of megakaryocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of miRNA transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of miRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of forebrain neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of primitive erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to lipid IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within semicircular canal development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within urogenital system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventral spinal cord interneuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    endothelial transcription factor GATA-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355253.1NP_001342182.1  endothelial transcription factor GATA-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AB000096, AW492264
      Consensus CDS
      CCDS20333.1
      UniProtKB/Swiss-Prot
      O09100
      UniProtKB/TrEMBL
      Q3U320, Q9DC59
      Related
      ENSMUSP00000128198.2, ENSMUST00000170089.8
      Conserved Domains (1) summary
      cd00202
      Location:349398
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    2. NM_008090.5NP_032116.4  endothelial transcription factor GATA-2

      See identical proteins and their annotated locations for NP_032116.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB000096, AW492264, BC107009, BY132907
      Consensus CDS
      CCDS20333.1
      UniProtKB/Swiss-Prot
      O09100
      UniProtKB/TrEMBL
      Q3U320, Q9DC59
      Related
      ENSMUSP00000015197.8, ENSMUST00000015197.9
      Conserved Domains (1) summary
      cd00202
      Location:349398
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      88170873..88184014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)