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    Ces2e carboxylesterase 2E [ Mus musculus (house mouse) ]

    Gene ID: 234673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ces2eprovided by MGI
    Official Full Name
    carboxylesterase 2Eprovided by MGI
    Primary source
    MGI:MGI:2443170
    See related
    Ensembl:ENSMUSG00000031886 AllianceGenome:MGI:2443170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ces5; 9030624L02Rik
    Summary
    Enables carboxylesterase activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in alimentary system; liver; and liver lobe. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 206.8), large intestine adult (RPKM 204.6) and 3 other tissues See more
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    Genomic context

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    See Ces2e in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105652892..105661304)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104926260..104934672)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33218 Neighboring gene carboxylesterase 2D, pseudogene Neighboring gene predicted gene, 33141 Neighboring gene carboxylesterase 2 pseudogene Neighboring gene carboxylesterase 2F Neighboring gene carboxylesterase 2G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. Stok JE, et al. J Biol Chem, 2004 Jul 9. PMID 15123619
    2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinyl-palmitate esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-permethrin hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pyrethroid hydrolase Ces2e
    Names
    carboxylesterase 5
    carboxylic ester hydrolase
    NP_001157228.1
    NP_766347.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163756.1 → NP_001157228.1  pyrethroid hydrolase Ces2e precursor

      See identical proteins and their annotated locations for NP_001157228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC166833, AK077248, BB806111
      Consensus CDS
      CCDS22588.1
      UniProtKB/Swiss-Prot
      Q8BK48, Q8BM97, Q8VC02
      Related
      ENSMUSP00000105037.3, ENSMUST00000109410.4
      Conserved Domains (2) summary
      COG0657
      Location:128 → 231
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30 → 538
      COesterase; Carboxylesterase family

    2. NM_172759.3 → NP_766347.1  pyrethroid hydrolase Ces2e precursor

      See identical proteins and their annotated locations for NP_766347.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC166833, AK077248
      Consensus CDS
      CCDS22588.1
      UniProtKB/Swiss-Prot
      Q8BK48, Q8BM97, Q8VC02
      Related
      ENSMUSP00000034355.5, ENSMUST00000034355.11
      Conserved Domains (2) summary
      COG0657
      Location:128 → 231
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30 → 538
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105652892..105661304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BK48.1 GenPept UniProtKB/Swiss-Prot:Q8BK48

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