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    Tm2d1 TM2 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 94043, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Tm2d1provided by MGI
    Official Full Name
    TM2 domain containing 1provided by MGI
    Primary source
    MGI:MGI:2137022
    See related
    Ensembl:ENSMUSG00000028563 AllianceGenome:MGI:2137022
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bbp; 2310026L18Rik
    Summary
    Enables G protein-coupled receptor activity and amyloid-beta binding activity. Acts upstream of or within apoptotic signaling pathway. Located in plasma membrane. Orthologous to human TM2D1 (TM2 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.6), placenta adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tm2d1 in Genome Data Viewer
    Location:
    4 C6; 4 45.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (98243607..98271523, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (98355370..98383265, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10844 Neighboring gene STARR-seq mESC enhancer starr_10845 Neighboring gene predicted gene 12787 Neighboring gene RIKEN cDNA 0610025J13 gene Neighboring gene STARR-seq mESC enhancer starr_10846 Neighboring gene STARR-seq mESC enhancer starr_10847 Neighboring gene PATJ, crumbs cell polarity complex component Neighboring gene STARR-seq mESC enhancer starr_10849 Neighboring gene STARR-seq mESC enhancer starr_10850 Neighboring gene predicted gene, 40210 Neighboring gene ornithine decarboxylase, structural 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. Kajkowski EM, et al. J Biol Chem, 2001 Jun 1. PMID 11278849
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TM2 domain-containing protein 1
    Names
    amyloid-beta-binding protein
    beta-amyloid binding protein
    mBBP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053157.2 → NP_444387.1  TM2 domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_444387.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089492
      Consensus CDS
      CCDS18374.1
      UniProtKB/Swiss-Prot
      A2ADR1, A2ADR4, Q99MB3
      Related
      ENSMUSP00000099855.5, ENSMUST00000102793.11
      Conserved Domains (1) summary
      pfam05154
      Location:118 → 167
      TM2; TM2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      98243607..98271523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164579.1 → XP_036020472.1  TM2 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam05154
      Location:118 → 167
      TM2; TM2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MB3.1 GenPept UniProtKB/Swiss-Prot:Q99MB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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