Cyp4a12a cytochrome P450, family 4, subfamily a, polypeptide 12a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp4a12aprovided by MGI
Official Full Name: cytochrome P450, family 4, subfamily a, polypeptide 12aprovided by MGI
Primary source: MGI:MGI:88612
See related: Ensembl:ENSMUSG00000066071 AllianceGenome:MGI:88612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp4a12
Summary: Enables alkane 1-monooxygenase activity and arachidonate omega-hydroxylase activity. Involved in omega-hydroxylase P450 pathway. Predicted to be located in apical plasma membrane; endoplasmic reticulum membrane; and extracellular space. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver; metanephros; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 21.2), genital fat pad adult (RPKM 7.2) and 2 other tissues See more
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Genomic context

Location:: 4 D1; 4 52.91 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (115156243..115190012)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (115299046..115332815)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enzyme is the predominant 20-hydroxyeicosatetraenoic synthase in mouse kidney.
Title: Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.

Submit: New GeneRIF Correction

General gene information

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Markers

Cyp4a12b (e-PCR), detects polymorphism
- UniSTS:545922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 16-hydroxypalmitate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables alkane 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkane 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkane 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables leukotriene-B4 20-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in icosanoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in omega-hydroxylase P450 pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 4A12A

Names: CYPIVA12; cytochrome P450, family 4, subfamily a, polypeptide 12

NP_803125.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.