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    Tmco3 transmembrane and coiled-coil domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 234076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmco3provided by MGI
    Official Full Name
    transmembrane and coiled-coil domains 3provided by MGI
    Primary source
    MGI:MGI:2444946
    See related
    Ensembl:ENSMUSG00000038497 AllianceGenome:MGI:2444946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230339H12Rik
    Summary
    Predicted to enable potassium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport and proton transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including cardiovascular system; central nervous system; gut; male reproductive gland or organ; and respiratory system. Orthologous to human TMCO3 (transmembrane and coiled-coil domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 21.8), kidney adult (RPKM 11.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmco3 in Genome Data Viewer
    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13333214..13372924)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13288013..13322924)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene predicted gene, 25014 Neighboring gene STARR-positive B cell enhancer ABC_E6621 Neighboring gene transcription factor Dp 1 Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMCO3, a Putative K(+) :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans. Holling T, et al. J Bone Miner Res, 2023 Sep. PMID 37554015
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMCO3, a Putative K[+] :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans.
      Title: TMCO3, a Putative K(+) :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables potassium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364217.1 → NP_001351146.1  transmembrane and coiled-coil domain-containing protein 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK046065, AK148252
      Conserved Domains (2) summary
      pfam00999
      Location:274 → 645
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      cl25732
      Location:61 → 253
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_172282.2 → NP_758486.1  transmembrane and coiled-coil domain-containing protein 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK033499, AK148252, BY146007
      Consensus CDS
      CCDS40231.1
      UniProtKB/Swiss-Prot
      Q3UFX1, Q7TMT5, Q8BGL4, Q8BH01, Q8R303
      Related
      ENSMUSP00000040347.6, ENSMUST00000045229.7
      Conserved Domains (2) summary
      pfam00999
      Location:274 → 646
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      pfam01519
      Location:88 → 195
      DUF16; Protein of unknown function DUF16

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13333214..13372924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153885.1 → XP_036009778.1  transmembrane and coiled-coil domain-containing protein 3 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:61 → 253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl01133
      Location:274 → 356
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RNA

    1. XR_004934801.1 RNA Sequence

    2. XR_004934800.1 RNA Sequence

    3. XR_003947253.2 RNA Sequence

    4. XR_001778426.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH01.1 GenPept UniProtKB/Swiss-Prot:Q8BH01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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