Rgs16 regulator of G-protein signaling 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs16provided by MGI
Official Full Name: regulator of G-protein signaling 16provided by MGI
Primary source: MGI:MGI:108407
See related: Ensembl:ENSMUSG00000026475 AllianceGenome:MGI:108407
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rgsr; Rgs14
Summary: Enables GTPase activator activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of GTPase activity. Located in membrane. Is expressed in several structures, including central nervous system; limb mesenchyme; lip; neural retina; and skeletal musculature. Orthologous to human RGS16 (regulator of G protein signaling 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E18 (RPKM 12.8), CNS E11.5 (RPKM 10.4) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 65.43 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (153616099..153621212)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (153740353..153745468)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury.
Title: Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury.
Rgs16 promotes antitumor CD8(+) T cell exhaustion.
Title: Rgs16 promotes antitumor CD8(+) T cell exhaustion.
RGS 16 has critical roles in regulating hemostatic and thrombotic functions of platelets in mice.
Title: Regulator of G-Protein Signaling 16 Is a Negative Modulator of Platelet Function and Thrombosis.
This study reveals how RGS proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking.
Title: Normal Thymocyte Egress, T Cell Trafficking, and CD4(+) T Cell Homeostasis Require Interactions between RGS Proteins and Gα(i2).
Findings indicate that regulator of G-protein signaling 16 (RGS16) plays an important role in platelet function by modulating CXCL12-dependent platelet activation.
Title: CXCL12 regulates platelet activation via the regulator of G-protein signaling 16.
RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-mediated pulmonary inflammation.
Title: RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
Gene ablation of Rgs16 leads to the loss of circadian production of cAMP and as a result lengthens circadian period of behavioural rhythm.
Title: Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus.
RGS16 provides a signaling mechanism for glucose production to inhibit GPCR-stimulated fatty acid oxidation in hepatocytes
Title: Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner.
The present study suggests that liver and/or thalamus regulate the food-entrained circadian behavior through G protein-mediated signal transduction pathway(s).
Title: Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice.
Rgs16 and Rgs8 are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults.
Title: Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

General gene information

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Markers

U94828 (e-PCR)
- UniSTS:158867

Rgs16 (e-PCR), detects polymorphism
- UniSTS:275689

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 16

Names: A28-RGS14P; RGS-R; retinal-specific RGS; retinally abundant regulator of G-protein signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011267.4 → NP_035397.2 regulator of G-protein signaling 16

See identical proteins and their annotated locations for NP_035397.2

Status: VALIDATED

Source sequence(s)

AC154140

Consensus CDS

CCDS15376.1

UniProtKB/Swiss-Prot

O09091, P97420, P97428, Q80V16

UniProtKB/TrEMBL

Q542U0

Related

ENSMUSP00000027748.8, ENSMUST00000027748.8

Conserved Domains (1) summary

cd08710
Location:65 → 178

RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein