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    Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 [ Mus musculus (house mouse) ]

    Gene ID: 234663, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dync1li2provided by MGI
    Official Full Name
    dynein, cytoplasmic 1 light intermediate chain 2provided by MGI
    Primary source
    MGI:MGI:107738
    See related
    Ensembl:ENSMUSG00000035770 AllianceGenome:MGI:107738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LIC2; Dlic2; Dncli2; Dnclic2; C920003I06
    Summary
    Predicted to enable dynein heavy chain binding activity and identical protein binding activity. Acts upstream of or within centrosome localization and microtubule cytoskeleton organization. Predicted to be located in kinetochore and late endosome. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Orthologous to human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 27.9), frontal lobe adult (RPKM 24.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Dync1li2 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105144306..105170415, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104417674..104443050, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CKLF-like MARVEL transmembrane domain containing 3 Neighboring gene CKLF-like MARVEL transmembrane domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E11745 Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene predicted gene, 22148 Neighboring gene STARR-positive B cell enhancer ABC_E6676 Neighboring gene NEDD8 activating enzyme E1 subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of dynein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytoplasmic dynein 1 light intermediate chain 2
    Names
    dynein light intermediate chain 2, cytosolic
    dynein, cytoplasmic, light intermediate chain 2
    dynein, cytoplasmic, light intermediate polypeptide 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013380.2NP_001013398.2  cytoplasmic dynein 1 light intermediate chain 2

      See identical proteins and their annotated locations for NP_001013398.2

      Status: VALIDATED

      Source sequence(s)
      AK140743, AK147899, BU850577, BY290848, CD351101
      Consensus CDS
      CCDS22579.1
      UniProtKB/Swiss-Prot
      Q3UGJ3, Q6PDL0
      UniProtKB/TrEMBL
      A0A1D5RM94
      Related
      ENSMUSP00000045480.7, ENSMUST00000041769.8
      Conserved Domains (4) summary
      cd00009
      Location:46100
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      pfam05783
      Location:30488
      DLIC; Dynein light intermediate chain (DLIC)
      pfam13257
      Location:374473
      DUF4048; Domain of unknown function (DUF4048)
      cl21455
      Location:218294
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105144306..105170415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530882.5XP_006530945.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5RM94
      Related
      ENSMUSP00000148716.2, ENSMUST00000212230.2
      Conserved Domains (1) summary
      pfam05783
      Location:30474
      DLIC; Dynein light intermediate chain (DLIC)
    2. XM_006530881.5XP_006530944.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RM94
      Conserved Domains (1) summary
      pfam05783
      Location:30446
      DLIC; Dynein light intermediate chain (DLIC)
    3. XM_006530880.5XP_006530943.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RM94
      Conserved Domains (1) summary
      pfam05783
      Location:30460
      DLIC; Dynein light intermediate chain (DLIC)
    4. XM_006530883.5XP_006530946.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X4

      Conserved Domains (1) summary
      pfam05783
      Location:30367
      DLIC; Dynein light intermediate chain (DLIC)