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    Phf7 PHD finger protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 71838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phf7provided by MGI
    Official Full Name
    PHD finger protein 7provided by MGI
    Primary source
    MGI:MGI:1919088
    See related
    Ensembl:ENSMUSG00000021902 AllianceGenome:MGI:1919088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700006H01Rik; 1700010P14Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in nucleus. Orthologous to human PHF7 (PHD finger protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 488.0) See more
    Orthologs
    human all
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    Genomic context

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    See Phf7 in Genome Data Viewer
    Location:
    14 B; 14 19.09 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30959646..30973327, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31237689..31251344, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene troponin C, cardiac/slow skeletal Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G Neighboring gene STARR-positive B cell enhancer ABC_E7302 Neighboring gene Brca1 associated protein 1 Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene STARR-positive B cell enhancer ABC_E10823

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phf7 has impacts on the body growth and bone remodeling by regulating testicular hormones in male mice. Kim JE, et al. Biochem Biophys Res Commun, 2024 Apr 16. PMID 38430697
    2. The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming. Garry GA, et al. Nat Cell Biol, 2021 May. PMID 33941892, Free PMC Article
    3. PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis. Kim CR, et al. Cell Rep, 2020 Jul 28. PMID 32726616
    4. PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis. Wang X, et al. Development, 2019 Jul 10. PMID 31189663
    5. NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis. Xiao J, et al. Biochem Biophys Res Commun, 2002 Feb 15. PMID 11829468

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phf7 has impacts on the body growth and bone remodeling by regulating testicular hormones in male mice.
      Title: Phf7 has impacts on the body growth and bone remodeling by regulating testicular hormones in male mice.
    2. The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming.
      Title: The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming.
    3. PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis.
      Title: PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis.
    4. PHF7 is a novel E3 ligase that can specifically ubiquitylate H2A through binding H3K4me3/me2 prior to histone-to-protamine exchange.
      Title: PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis.
    5. validated as novel and reliable, tissue-specific reference gene in qRT-PCR studies of postnatal mammary gland development
      Title: Identification of reliable reference genes for qRT-PCR studies of the developing mouse mammary gland.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 7
    Names
    testis development protein NYD-SP6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360624.1 → NP_001347553.1  PHD finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC049113, BM937743
      Consensus CDS
      CCDS88616.1
      Related
      ENSMUSP00000154095.2, ENSMUST00000226565.2
      Conserved Domains (2) summary
      cd15669
      Location:33 → 144
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl22851
      Location:225 → 261
      PHD_SF; PHD finger superfamily

    2. NM_001360625.1 → NP_001347554.1  PHD finger protein 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK005852, BC049113, BC145337, BM937743
      Consensus CDS
      CCDS88614.1
      UniProtKB/TrEMBL
      B7ZNN0
      Related
      ENSMUSP00000154738.2, ENSMUST00000228437.2
      Conserved Domains (2) summary
      cd15496
      Location:152 → 205
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl22851
      Location:33 → 97
      PHD_SF; PHD finger superfamily

    3. NM_027949.2 → NP_082225.1  PHD finger protein 7 isoform 1

      See identical proteins and their annotated locations for NP_082225.1

      Status: VALIDATED

      Source sequence(s)
      AK005852, BC049113, BM937743
      Consensus CDS
      CCDS26909.1
      UniProtKB/Swiss-Prot
      Q6PG81, Q9DAG9
      UniProtKB/TrEMBL
      A2RTI5
      Related
      ENSMUSP00000022459.4, ENSMUST00000022459.5
      Conserved Domains (2) summary
      cd15496
      Location:247 → 300
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cd15669
      Location:33 → 144
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

    RNA

    1. NR_153760.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK005852, BC049113, BC145338, BM937743

    2. NR_153761.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108416, AK005852, BC049113, BM937743
      Related
      ENSMUST00000226310.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30959646..30973327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245202.4 → XP_011243504.1  PHD finger protein 7 isoform X1

      Conserved Domains (1) summary
      cd15669
      Location:33 → 144
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

    2. XM_011245203.4 → XP_011243505.1  PHD finger protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BR08
      Related
      ENSMUSP00000154281.2, ENSMUST00000228930.2
      Conserved Domains (1) summary
      cd15669
      Location:33 → 138
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAG9.1 GenPept UniProtKB/Swiss-Prot:Q9DAG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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