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    Rassf6 Ras association (RalGDS/AF-6) domain family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 73246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rassf6provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family member 6provided by MGI
    Primary source
    MGI:MGI:1920496
    See related
    Ensembl:ENSMUSG00000029370 AllianceGenome:MGI:1920496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1600016B17Rik
    Summary
    Involved in regulation of apoptotic process. Acts upstream of or within positive regulation of apoptotic process. Is expressed in gut; liver lobe; urinary system; and vibrissa. Orthologous to human RASSF6 (Ras association domain family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 6.2), colon adult (RPKM 3.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rassf6 in Genome Data Viewer
    Location:
    5 E1; 5 44.78 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90750933..90788594, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90603076..90640734, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene albumin superfamily member 1 Neighboring gene predicted gene, 42109 Neighboring gene STARR-positive B cell enhancer ABC_E4764 Neighboring gene STARR-seq mESC enhancer starr_13601 Neighboring gene STARR-seq mESC enhancer starr_13602 Neighboring gene STARR-seq mESC enhancer starr_13603 Neighboring gene predicted gene, 36084 Neighboring gene C-X-C motif chemokine ligand 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RASSF6 expression in adipocytes is down-regulated by interaction with macrophages. Sanada Y, et al. PLoS One, 2013. PMID 23626755, Free PMC Article
    2. Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-κB signaling. Morishita M, et al. Genes Cells, 2021 Dec. PMID 34652874
    3. RASSF6 is a novel member of the RASSF family of tumor suppressors. Allen NP, et al. Oncogene, 2007 Sep 13. PMID 17404571
    4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    5. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-kappaB signaling.
      Title: Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-κB signaling.
    2. RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.
      Title: RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.
    3. Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members.
      Title: RASSF6 is a novel member of the RASSF family of tumor suppressors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310656.2 → NP_001297585.1  ras association domain-containing protein 6 isoform 2

      See identical proteins and their annotated locations for NP_001297585.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC135240
      Consensus CDS
      CCDS80327.1
      UniProtKB/Swiss-Prot
      Q80UQ2
      Related
      ENSMUSP00000144337.2, ENSMUST00000202784.4
      Conserved Domains (2) summary
      pfam16517
      Location:278 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:178 → 264
      UBQ; Ubiquitin-like proteins

    2. NM_001407901.1 → NP_001394830.1  ras association domain-containing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC135240
      UniProtKB/Swiss-Prot
      G3X8Z9, Q80UQ2, Q9DAW2

    3. NM_001407903.1 → NP_001394832.1  ras association domain-containing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC135240
      UniProtKB/Swiss-Prot
      G3X8Z9, Q80UQ2, Q9DAW2
      Related
      ENSMUSP00000144532.2, ENSMUST00000202704.4

    4. NM_001407905.1 → NP_001394834.1  ras association domain-containing protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC135240

    5. NM_028478.4 → NP_082754.2  ras association domain-containing protein 6 isoform 1

      See identical proteins and their annotated locations for NP_082754.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC135240
      Consensus CDS
      CCDS39142.1
      UniProtKB/Swiss-Prot
      G3X8Z9, Q80UQ2, Q9DAW2
      Related
      ENSMUSP00000031317.7, ENSMUST00000031317.10
      Conserved Domains (2) summary
      pfam16517
      Location:291 → 329
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:191 → 277
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RNA

    1. NR_176431.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC135240

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      90750933..90788594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249579.4 → XP_011247881.1  ras association domain-containing protein 6 isoform X5

      See identical proteins and their annotated locations for XP_011247881.1

      Conserved Domains (1) summary
      cl28922
      Location:38 → 124
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_006535245.4 → XP_006535308.1  ras association domain-containing protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006535308.1

      UniProtKB/Swiss-Prot
      G3X8Z9, Q80UQ2, Q9DAW2
      Conserved Domains (2) summary
      pfam16517
      Location:291 → 329
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:191 → 277
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_006535244.4 → XP_006535307.1  ras association domain-containing protein 6 isoform X2

      Conserved Domains (2) summary
      pfam16517
      Location:307 → 345
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:207 → 293
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_006535241.3 → XP_006535304.1  ras association domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006535304.1

      Conserved Domains (2) summary
      pfam16517
      Location:320 → 358
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:220 → 306
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. XM_006535249.4 → XP_006535312.1  ras association domain-containing protein 6 isoform X4

      Conserved Domains (2) summary
      pfam16517
      Location:233 → 271
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:133 → 219
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    6. XM_006535243.5 → XP_006535306.1  ras association domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006535306.1

      Conserved Domains (2) summary
      pfam16517
      Location:320 → 358
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:220 → 306
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    7. XM_006535242.5 → XP_006535305.1  ras association domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006535305.1

      Conserved Domains (2) summary
      pfam16517
      Location:320 → 358
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:220 → 306
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RNA

    1. XR_001784751.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UQ2.2 GenPept UniProtKB/Swiss-Prot:Q80UQ2

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