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    Dynlt1f dynein light chain Tctex-type 1F [ Mus musculus (house mouse) ]

    Gene ID: 100040531, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dynlt1fprovided by MGI
    Official Full Name
    dynein light chain Tctex-type 1Fprovided by MGI
    Primary source
    MGI:MGI:3780996
    See related
    Ensembl:ENSMUSG00000095677 AllianceGenome:MGI:3780996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AGS2; Dynlt1; Tctel1; Tctex1; Dynlt1e; Tctex-1; 100040631
    Summary
    Predicted to enable identical protein binding activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including cardiac muscle cell apoptotic process; intracellular transport of viral protein in host cell; and neuron projection development. Predicted to be located in axonal growth cone; lamellipodium; and neuronal cell body. Predicted to be part of dynein complex. Orthologous to human DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 181.1), CNS E14 (RPKM 69.7) and 27 other tissues See more
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    Genomic context

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    See Dynlt1f in Genome Data Viewer
    Location:
    17 A1; 17 4.11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6914005..6923338, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6646606..6655965, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancers mm9_chr17:6806288-6806589 and mm9_chr17:6654863-6655163 Neighboring gene transmembrane protein 181C, pseudogene Neighboring gene dynein light chain Tctex-type 1C Neighboring gene STARR-positive B cell enhancers mm9_chr17:6600655-6600955 and mm9_chr17:6860503-6860804 Neighboring gene synaptotagmin-like 3 Neighboring gene predicted gene, 36309 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:6949847-6950048 Neighboring gene STARR-seq mESC enhancer starr_41734 Neighboring gene ezrin Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:6982099-6982286 Neighboring gene STARR-positive B cell enhancer ABC_E2469

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Ha H, et al. Dev Genet, 1991. PMID 1718647
    2. Genetic and molecular analysis of the proximal region of the mouse t-complex using new molecular probes and partial t-haplotypes. Howard CA, et al. Genetics, 1990 Dec. PMID 2076813, Free PMC Article
    3. Cytoplasmic dynein nomenclature. Pfister KK, et al. J Cell Biol, 2005 Nov 7. PMID 16260502, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular transport of viral protein in host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein light chain Tctex-type 1F
    Names
    Activator of G-protein signaling 2
    Dynein light chain Tctex-type 1
    T-complex testis-specific protein 1
    dynein light chain Tctex-type 1E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166627.1 → NP_001160099.1  dynein light chain Tctex-type 1F isoform 1

      See identical proteins and their annotated locations for NP_001160099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BQ175560, BY250333
      Consensus CDS
      CCDS57043.1
      UniProtKB/Swiss-Prot
      P51807, Q5M8S6
      UniProtKB/TrEMBL
      A1E5T5
      Related
      ENSMUSP00000135978.2, ENSMUST00000179554.3
      Conserved Domains (1) summary
      pfam03645
      Location:16 → 111
      Tctex-1; Tctex-1 family

    2. NM_001199948.1 → NP_001186877.1  dynein light chain Tctex-type 1F isoform 2

      See identical proteins and their annotated locations for NP_001186877.1

      Status: VALIDATED

      Source sequence(s)
      AC175035, AK005569, BE952651
      UniProtKB/TrEMBL
      A0A338P7B7, Q9DAS3
      Conserved Domains (1) summary
      pfam03645
      Location:16 → 90
      Tctex-1; Tctex-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      6914005..6923338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001199947.1: Suppressed sequence

      Description
      NM_001199947.1: This RefSeq was permanently suppressed because it was redundant with NM_001166627.1.
    Nucleotide Protein Strain
    Heading Accession and Version

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