Adap2 ArfGAP with dual PH domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adap2provided by MGI
Official Full Name: ArfGAP with dual PH domains 2provided by MGI
Primary source: MGI:MGI:2663075
See related: Ensembl:ENSMUSG00000020709 AllianceGenome:MGI:2663075
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Centa2
Summary: Predicted to enable GTPase activator activity; anion binding activity; and phosphatidylinositol binding activity. Predicted to be involved in heart development. Predicted to be located in mitochondrial envelope. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. Is expressed in several structures, including brain; future brain; heart; inner ear; and limb bud. Orthologous to human ADAP2 (ArfGAP with dual PH domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 6.0), liver adult (RPKM 4.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 47.56 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (80044869..80071449)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (80154044..80178827)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAP2 has a role in heart development, and might be a reliable candidate gene for the occurrence of cardiovascular malformations in patients with NF1 microdeletion.
Title: ADAP2 in heart development: a candidate gene for the occurrence of cardiovascular malformations in NF1 microdeletion syndrome.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Centa2 (e-PCR), detects polymorphism
- UniSTS:498226

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,3,4,5 tetrakisphosphate binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,3,4,5 tetrakisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial envelope	ISO Inferred from Sequence Orthology more info
located_in mitochondrial envelope	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: arf-GAP with dual PH domain-containing protein 2

Names: centaurin, alpha 2; cnt-a2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172133.1 → NP_742145.1 arf-GAP with dual PH domain-containing protein 2

See identical proteins and their annotated locations for NP_742145.1

Status: PROVISIONAL

Source sequence(s)

BC027165

Consensus CDS

CCDS25128.1

UniProtKB/Swiss-Prot

Q8R2V5

UniProtKB/TrEMBL

Q3V340, Q5SSK2

Related

ENSMUSP00000021050.8, ENSMUST00000021050.14

Conserved Domains (4) summary

cd01251
Location:255 → 362

PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2

cd13252
Location:133 → 241

PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

pfam00169
Location:135 → 231

PH; PH domain

pfam01412
Location:9 → 123

ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

80044869..80071449

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156584.1 → XP_036012477.1 arf-GAP with dual PH domain-containing protein 2 isoform X2

Conserved Domains (2) summary

cd13252
Location:133 → 241

PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

cl28907
Location:4 → 117

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
XM_036156583.1 → XP_036012476.1 arf-GAP with dual PH domain-containing protein 2 isoform X1

Conserved Domains (3) summary

cd01251
Location:179 → 286

PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2

cd13252
Location:57 → 165

PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

cl28907
Location:1 → 41

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)