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    Nt5dc2 5'-nucleotidase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nt5dc2provided by MGI
    Official Full Name
    5'-nucleotidase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917271
    See related
    Ensembl:ENSMUSG00000071547 AllianceGenome:MGI:1917271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510015F01Rik
    Summary
    Predicted to enable 5'-nucleotidase activity. Is expressed in several structures, including brain; craniocervical region bone; eye; gut gland; and urinary system. Orthologous to human NT5DC2 (5'-nucleotidase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 90.6), limb E14.5 (RPKM 86.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nt5dc2 in Genome Data Viewer
    Location:
    14 B; 14 19.09 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30853046..30861081)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31131089..31139124)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene polybromo 1 Neighboring gene predicted gene 5459 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E934 Neighboring gene stabilin 1 Neighboring gene predicted gene, 52148 Neighboring gene nischarin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple-negative breast cancer by blocking the EGFR pathway. Sang R, et al. Mol Carcinog, 2024 Apr. PMID 38289126
    2. Investigation of differentially expressed genes during the development of mouse cerebellum. Kagami Y, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018818
    3. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Choquet H, et al. Nat Commun, 2021 Jun 14. PMID 34127677, Free PMC Article
    4. Gene expression analysis of the embryonic subplate. Oeschger FM, et al. Cereb Cortex, 2012 Jun. PMID 21862448, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple-negative breast cancer by blocking the EGFR pathway.
      Title: NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple-negative breast cancer by blocking the EGFR pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    5'-nucleotidase domain-containing protein 2
    NP_001361016.1
    NP_081565.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374087.1 → NP_001361016.1  5'-nucleotidase domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154446
      Consensus CDS
      CCDS88613.1
      UniProtKB/TrEMBL
      A0A2I3BR81, A0A2I3BRL0
      Related
      ENSMUSP00000154475.2, ENSMUST00000227096.2
      Conserved Domains (1) summary
      pfam05761
      Location:97 → 530
      5_nucleotid; 5' nucleotidase family

    2. NM_027289.2 → NP_081565.1  5'-nucleotidase domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_081565.1

      Status: VALIDATED

      Source sequence(s)
      AC154446
      Consensus CDS
      CCDS36852.1
      UniProtKB/TrEMBL
      A0A2I3BQR1, Q91X76
      Related
      ENSMUSP00000087680.5, ENSMUST00000090212.5
      Conserved Domains (1) summary
      pfam05761
      Location:1 → 367
      5_nucleotid; 5' nucleotidase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30853046..30861081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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