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    Spa17 sperm autoantigenic protein 17 [ Mus musculus (house mouse) ]

    Gene ID: 20686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spa17provided by MGI
    Official Full Name
    sperm autoantigenic protein 17provided by MGI
    Primary source
    MGI:MGI:1333778
    See related
    Ensembl:ENSMUSG00000001948 AllianceGenome:MGI:1333778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sp17
    Summary
    Predicted to enable calmodulin binding activity. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Located in several cellular components, including external side of plasma membrane; neuron projection; and sperm flagellum. Is expressed in several structures, including brain; gonad; heart; hemolymphoid system gland; and lung. Orthologous to human SPA17 (sperm autoantigenic protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 108.0) and CNS E11.5 (RPKM 4.0) See more
    Orthologs
    human all
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    Genomic context

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    See Spa17 in Genome Data Viewer
    Location:
    9 A4; 9 20.78 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (37514590..37525018, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (37603294..37613916, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23812 Neighboring gene neurogranin Neighboring gene predicted gene, 46107 Neighboring gene STARR-positive B cell enhancer ABC_E1111 Neighboring gene sialic acid acetylesterase Neighboring gene STARR-seq mESC enhancer starr_23813 Neighboring gene transforming growth factor beta regulated gene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma. Bumm K, et al. Hum Pathol, 2005 Dec. PMID 16311122
    2. A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding. Frayne J, et al. Reproduction, 2002 Dec. PMID 12530914
    3. Identification of target messenger RNA substrates for mouse RBMY. Zeng M, et al. Mol Hum Reprod, 2008 Jun. PMID 18492746
    4. Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction. Richardson RT, et al. Dev Biol, 1994 Oct. PMID 7525387
    5. Sequence and localization of the mouse sperm autoantigenic protein, Sp17. Kong M, et al. Biol Reprod, 1995 Sep. PMID 7578682

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within binding of sperm to zona pellucida TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm fibrous sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sperm surface protein Sp17
    Names
    band 34
    sperm protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324545.2 → NP_001311474.1  sperm surface protein Sp17

      Status: VALIDATED

      Source sequence(s)
      AC160125
      Consensus CDS
      CCDS22982.1
      UniProtKB/Swiss-Prot
      Q62252
      UniProtKB/TrEMBL
      A0A1L1SU87, Q545M2
      Related
      ENSMUSP00000150651.2, ENSMUST00000214786.2
      Conserved Domains (1) summary
      cd12100
      Location:12 → 50
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    2. NM_011449.3 → NP_035579.1  sperm surface protein Sp17

      See identical proteins and their annotated locations for NP_035579.1

      Status: VALIDATED

      Source sequence(s)
      AC160125
      Consensus CDS
      CCDS22982.1
      UniProtKB/Swiss-Prot
      Q62252
      UniProtKB/TrEMBL
      A0A1L1SU87, Q545M2
      Related
      ENSMUSP00000002013.10, ENSMUST00000002013.11
      Conserved Domains (1) summary
      cd12100
      Location:12 → 50
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    RNA

    1. NR_177074.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC160125

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      37514590..37525018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62252.1 GenPept UniProtKB/Swiss-Prot:Q62252

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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