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    Atp5pf ATP synthase peripheral stalk subunit F6 [ Mus musculus (house mouse) ]

    Gene ID: 11957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp5pfprovided by MGI
    Official Full Name
    ATP synthase peripheral stalk subunit F6provided by MGI
    Primary source
    MGI:MGI:107777
    See related
    Ensembl:ENSMUSG00000022890 AllianceGenome:MGI:107777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CF6; Atp5j
    Summary
    The protein encoded by this gene is a component of mitochondrial adenosine triphosphate synthase, which catalyzes the conversion of ATP from ADP. Mitochondrial adenosine triphosphate synthase consists of extrinsic and intrinsic membrane domains that are joined by a stalk. The protein encoded by this gene is a subunit of the stalk domain. A bi-directional promoter that drives expression of this gene has been has been identified. Pseudogenes of this gene are found on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in heart adult (RPKM 199.5), kidney adult (RPKM 107.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp5pf in Genome Data Viewer
    Location:
    16 C3.3; 16 46.92 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84624754..84632495, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84827871..84835857, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41365 Neighboring gene predicted gene, 32202 Neighboring gene STARR-seq mESC enhancer starr_41367 Neighboring gene junction adhesion molecule 2 Neighboring gene STARR-positive B cell enhancer ABC_E5555 Neighboring gene predicted gene, 46557 Neighboring gene GA repeat binding protein, alpha Neighboring gene STARR-seq mESC enhancer starr_41374 Neighboring gene STARR-seq mESC enhancer starr_41375 Neighboring gene predicted gene 10791 Neighboring gene amyloid beta precursor protein Neighboring gene predicted gene, 49227

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice. Izumiyama K, et al. Hypertens Res, 2012 May. PMID 22258022
    2. The ETS transcription factor GABPalpha is essential for early embryogenesis. Ristevski S, et al. Mol Cell Biol, 2004 Jul. PMID 15199140, Free PMC Article
    3. Isolation of a bi-directional promoter directing expression of the mouse GABPalpha and ATP synthase coupling factor 6 genes. Chinenov Y, et al. Gene, 2000 Dec 31. PMID 11167019
    4. Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice. Sagara S, et al. J Hypertens, 2012 Apr. PMID 22306848
    5. Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice. Osanai T, et al. Diabetologia, 2012 Feb. PMID 22038518

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coupling factor 6 overexpression induced salt-sensitive hypertension, complicated by systolic cardiac dysfunction, but its onset was delayed in females. Estrogen has an important role in the regulation of coupling factor 6-mediated pathophysiology.
      Title: Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice.
    2. Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by downregulating Akt signaling, thereby cancelling its benefit for cardiac function in mice.
      Title: Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.
    3. CF6 plays a crucial role in the development of insulin resistance and hypertension
      Title: Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.
    4. coupling factor 6 induces the development of systolic dysfunction and upregulation of nicotinamide adenine dinucleotide phosphate oxidase in the heart under the high-salt diet
      Title: Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice.
    5. identification of functional elements in bi-directional promoter
      Title: Identification of functional elements in the murine Gabp alpha/ATP synthase coupling factor 6 bi-directional promoter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of arachidonate secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase-coupling factor 6, mitochondrial
    Names
    ATP synthase coupling factor VI
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
    ATPase subunit F6
    NP_001289142.1
    NP_001289143.1
    NP_001289144.1
    NP_001289145.1
    NP_001345428.1
    NP_001345429.1
    NP_001403518.1
    NP_001403520.1
    NP_001403521.1
    NP_001403522.1
    NP_001403523.1
    NP_001403524.1
    NP_001403526.1
    NP_001403527.1
    NP_001403529.1
    NP_001403530.1
    NP_058035.1
    XP_030104798.1
    XP_036015646.1
    XP_036015647.1
    XP_036015648.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302213.2 → NP_001289142.1  ATP synthase-coupling factor 6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001289142.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
      Source sequence(s)
      AC164162
      Consensus CDS
      CCDS28283.1
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Related
      ENSMUSP00000109829.2, ENSMUST00000114191.8
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    2. NM_001302214.2 → NP_001289143.1  ATP synthase-coupling factor 6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001289143.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
      Source sequence(s)
      AC164162
      Consensus CDS
      CCDS28283.1
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    3. NM_001302215.2 → NP_001289144.1  ATP synthase-coupling factor 6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001289144.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
      Source sequence(s)
      AC164162
      Consensus CDS
      CCDS28283.1
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    4. NM_001302216.2 → NP_001289145.1  ATP synthase-coupling factor 6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001289145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
      Source sequence(s)
      AC164162
      Consensus CDS
      CCDS28283.1
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    5. NM_001358499.2 → NP_001345428.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
      Source sequence(s)
      AC164162
      Consensus CDS
      CCDS28283.1
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    6. NM_001358500.2 → NP_001345429.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
      Source sequence(s)
      AC164162
      Consensus CDS
      CCDS28283.1
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    7. NM_001416589.1 → NP_001403518.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    8. NM_001416591.1 → NP_001403520.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    9. NM_001416592.1 → NP_001403521.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    10. NM_001416593.1 → NP_001403522.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    11. NM_001416594.1 → NP_001403523.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    12. NM_001416595.1 → NP_001403524.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    13. NM_001416597.1 → NP_001403526.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    14. NM_001416598.2 → NP_001403527.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    15. NM_001416600.1 → NP_001403529.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    16. NM_001416601.1 → NP_001403530.1  ATP synthase-coupling factor 6, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6

    17. NM_016755.4 → NP_058035.1  ATP synthase-coupling factor 6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_058035.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
      Source sequence(s)
      AC164162
      Consensus CDS
      CCDS28283.1
      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Related
      ENSMUSP00000023608.8, ENSMUST00000023608.14
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    RNA

    1. NR_184383.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164162

    2. NR_184384.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164162

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      84624754..84632495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159754.1 → XP_036015647.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    2. XM_030248938.2 → XP_030104798.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    3. XM_036159755.1 → XP_036015648.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    4. XM_036159753.1 → XP_036015646.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P97450
      UniProtKB/TrEMBL
      E9QAD6
      Related
      ENSMUSP00000109831.2, ENSMUST00000114193.8
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 95
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97450.1 GenPept UniProtKB/Swiss-Prot:P97450

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