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    STK35 serine/threonine kinase 35 [ Homo sapiens (human) ]

    Gene ID: 140901, updated on 10-Dec-2024

    Summary

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    Official Symbol
    STK35provided by HGNC
    Official Full Name
    serine/threonine kinase 35provided by HGNC
    Primary source
    HGNC:HGNC:16254
    See related
    Ensembl:ENSG00000125834 MIM:609370; AllianceGenome:HGNC:16254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLIK1; STK35L1
    Summary
    The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 8.0), esophagus (RPKM 4.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK35 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (2101827..2148555)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (2131852..2178591)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2082473..2129201)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PDYN antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1974244-1975074 Neighboring gene Sharpr-MPRA regulatory region 7514 Neighboring gene prodynorphin Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2075323-2075824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2075825-2076324 Neighboring gene ribosomal protein L7 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12599 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2083234-2084202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12600 Neighboring gene uncharacterized LOC124900458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2126343-2127006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2131168-2131684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2131685-2132200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2143700-2144200 Neighboring gene uncharacterized LOC124904859 Neighboring gene uncharacterized LOC105372502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells. Goyal P, et al. PLoS One, 2011 Jan 20. PMID 21283756, Free PMC Article
    2. Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells. Wu Z, et al. Cell Physiol Biochem, 2018. PMID 29414823
    3. STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer. Yang H, et al. Front Cell Dev Biol, 2020. PMID 33117809, Free PMC Article
    4. Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. Vallenius T, et al. J Cell Sci, 2002 May 15. PMID 11973348
    5. Nuclear retention of importin α coordinates cell fate through changes in gene expression. Yasuda Y, et al. EMBO J, 2012 Jan 4. PMID 21964068, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
      Title: SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
    2. STK35 knockdown enhanced apoptosis. Expression of the active forms and the activity of two major executioner caspases, caspase 3 and caspase 7, were also increased in osteosarcoma cells with STK35 silenced.
      Title: Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
    3. constitutive overexpression of STK35 proteins enhances caspase-independent cell death under oxidative stress conditions.
      Title: Nuclear retention of importin α coordinates cell fate through changes in gene expression.
    4. by regulating CDKN2A and inhibiting G1- to S-phase transition STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells
      Title: STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells.
    5. analysis of the STK35L proteins in human and in sea squirts
      Title: Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates.
    6. results establish the CLP-36 PDZ-LIM protein as an adapter, recruiting the Clik1 kinase to actin stress fibers in nonmuscle cells, and suggest that Clik1 represents a novel regulator of actin stress fibers
      Title: Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 35
    Names
    CLIK-1
    CLP-36 interacting kinase
    CLP-36-interacting kinase 1
    PDLIM1-interacting kinase 1
    serine threonine kinase 35 long form
    serine/threonine-protein kinase 35 L1
    NP_543026.2
    XP_011527476.2
    XP_054179044.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080836.4 → NP_543026.2  serine/threonine-protein kinase 35

      See identical proteins and their annotated locations for NP_543026.2

      Status: REVIEWED

      Source sequence(s)
      AL359916, BC140884, GQ281297
      Consensus CDS
      CCDS13024.2
      UniProtKB/Swiss-Prot
      B2RBM3, C7ENV8, Q2NKW6, Q5T3R1, Q5T3R2, Q8TDR2, Q96AB4, Q9BZ06
      Related
      ENSP00000370891.3, ENST00000381482.8
      Conserved Domains (2) summary
      smart00220
      Location:202 → 523
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13977
      Location:201 → 529
      STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      2101827..2148555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529174.4 → XP_011527476.2  serine/threonine-protein kinase 35 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      2131852..2178591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323069.1 → XP_054179044.1  serine/threonine-protein kinase 35 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDR2.2 GenPept UniProtKB/Swiss-Prot:Q8TDR2

    Gene LinkOut

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