Apln apelin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aplnprovided by MGI
Official Full Name: apelinprovided by MGI
Primary source: MGI:MGI:1353624
See related: Ensembl:ENSMUSG00000037010 AllianceGenome:MGI:1353624
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Apel; 6030430G11Rik
Summary: This gene encodes the neuropeptide Apelin, an endogenous ligand of the G protein-coupled receptor APJ. This gene is highly expressed in the central nervous system and peripheral tissues and the encoded preproprotein undergoes proteolytic processing to generate mature peptides of different sizes that are secreted into the plasma. These peptides play important roles in a broad range of physiological processes such as cardiac contractility, blood pressure, blood vessel growth, appetite and drink behavior, and pituitary hormone secretion. Mice lacking the encoded protein develop progressive heart failure and exhibit a shorter bleeding time, prothrombotic profile and increased bone mass. [provided by RefSeq, Jul 2016]
Expression: Broad expression in lung adult (RPKM 12.2), cortex adult (RPKM 7.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A4; X 25.48 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (47114023..47123730, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (48025146..48034853, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hormonal dependent expression of apelin and apelin receptor in the ovary and uterus of mice.
Title: Hormonal dependent expression of apelin and apelin receptor in the ovary and uterus of mice.
Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model.
Title: Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model.
Expression of Apelin and Apelin Receptor Protein in the Hypothalamo-Pituitary-Ovarian Axis during the Estrous Cycle of Mice.
Title: Expression of Apelin and Apelin Receptor Protein in the Hypothalamo-Pituitary-Ovarian Axis during the Estrous Cycle of Mice.
Possible role of apelin on the ovarian steroidogenesis and uterine apoptosis of infantile mice: An in vitro study.
Title: Possible role of apelin on the ovarian steroidogenesis and uterine apoptosis of infantile mice: An in vitro study.
Postnatal developmental expression of apelin receptor proteins and its role in juvenile mice testis.
Title: Postnatal developmental expression of apelin receptor proteins and its role in juvenile mice testis.
Apelin Prevents and Alleviates Crystalline Silica-induced Pulmonary Fibrosis via Inhibiting Transforming Growth Factor Beta 1-triggered Fibroblast Activation.
Title: Apelin Prevents and Alleviates Crystalline Silica-induced Pulmonary Fibrosis via Inhibiting Transforming Growth Factor Beta 1-triggered Fibroblast Activation.
The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Title: The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Apelin triggers macrophage polarization to M2 type in head and neck cancer.
Title: Apelin triggers macrophage polarization to M2 type in head and neck cancer.
Cancer apelin receptor suppresses vascular mimicry in malignant melanoma.
Title: Cancer apelin receptor suppresses vascular mimicry in malignant melanoma.
The investigation of apelin and apelin receptor expressions in mouse endometrium during peri-implantation period.
Title: The investigation of apelin and apelin receptor expressions in mouse endometrium during peri-implantation period.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (10) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables apelin receptor binding	ISO Inferred from Sequence Orthology more info
enables apelin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apelin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in apelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apelin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in drinking behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin-releasing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heat generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of body fluid levels	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apelin

Names: APJ endogenous ligand; preproapelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.