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    Nub1 negative regulator of ubiquitin-like proteins 1 [ Mus musculus (house mouse) ]

    Gene ID: 53312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nub1provided by MGI
    Official Full Name
    negative regulator of ubiquitin-like proteins 1provided by MGI
    Primary source
    MGI:MGI:1889001
    See related
    Ensembl:ENSMUSG00000028954 AllianceGenome:MGI:1889001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BS4; NY-REN-18; 4931404D21Rik; 6330412F12Rik
    Summary
    Acts upstream of or within proteasomal protein catabolic process. Located in Lewy body and nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 36.3), lung adult (RPKM 24.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nub1 in Genome Data Viewer
    Location:
    5 A3; 5 11.93 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24890813..24915376)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24685815..24710378)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D3 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_12645 Neighboring gene STARR-positive B cell enhancer mm9_chr5:24180078-24180378 Neighboring gene STARR-positive B cell enhancer ABC_E1298 Neighboring gene STARR-positive B cell enhancer ABC_E11722 Neighboring gene WD repeat domain 86 Neighboring gene VISTA enhancer mm394 Neighboring gene predicted gene, 42231 Neighboring gene STARR-seq mESC enhancer starr_12647 Neighboring gene predicted gene, 33591 Neighboring gene crystallin, gamma N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins. Li J, et al. J Biol Chem, 2015 Sep 25. PMID 26260793, Free PMC Article
    2. The role of NUB1 in α-synuclein degradation in Lewy body disease model mice. Tanji K, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26797281
    3. Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L. Tanaka T, et al. J Biol Chem, 2003 Aug 29. PMID 12816948
    4. Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1. Kamitani T, et al. J Biol Chem, 2001 Dec 7. PMID 11585840
    5. NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression. Kito K, et al. J Biol Chem, 2001 Jun 8. PMID 11259415

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAT10 and NUB1L cooperate to activate the 26S proteasome.
      Title: FAT10 and NUB1L cooperate to activate the 26S proteasome.
    2. These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice.
      Title: The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.
    3. NUB1L suppresses atypical neddylation and promotes the degradation of misfolded proteins by the proteasome
      Title: NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins.
    4. NUB1 has a splicing variant, NUB1L, which regulates the NEDD8 conjugation system
      Title: Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within proteasomal protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Lewy body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD8 ultimate buster 1
    Names
    NY-REN-18 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305264.1 → NP_001292193.1  NEDD8 ultimate buster 1 isoform 1

      See identical proteins and their annotated locations for NP_001292193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC137938, AI853857, AK086301, AK153400
      Consensus CDS
      CCDS80230.1
      UniProtKB/TrEMBL
      A0A0G2JGQ4
      Related
      ENSMUSP00000143657.2, ENSMUST00000197407.5
      Conserved Domains (3) summary
      cd14291
      Location:399 → 434
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14293
      Location:516 → 551
      UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:457 → 491
      UBA_like_SF; UBA domain-like superfamily

    2. NM_016736.3 → NP_058016.2  NEDD8 ultimate buster 1 isoform 2

      See identical proteins and their annotated locations for NP_058016.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC137938, AI853857, AK086301, AK134581
      Consensus CDS
      CCDS39030.1
      UniProtKB/Swiss-Prot
      P54729, Q8K3U0
      UniProtKB/TrEMBL
      Q3UYM1
      Related
      ENSMUSP00000070265.7, ENSMUST00000068825.8
      Conserved Domains (3) summary
      cd14291
      Location:375 → 410
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14293
      Location:492 → 527
      UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:433 → 467
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      24890813..24915376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54729.2 GenPept UniProtKB/Swiss-Prot:P54729

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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