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    Dolpp1 dolichyl pyrophosphate phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 57170, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dolpp1provided by MGI
    Official Full Name
    dolichyl pyrophosphate phosphatase 1provided by MGI
    Primary source
    MGI:MGI:1914093
    See related
    Ensembl:ENSMUSG00000026856 AllianceGenome:MGI:1914093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LSFR2; 0610011H20Rik
    Summary
    Enables dolichyldiphosphatase activity. Involved in protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Is expressed in alimentary system; liver; nervous system; respiratory system; and urinary system. Orthologous to human DOLPP1 (dolichyldiphosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 22.0), duodenum adult (RPKM 19.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dolpp1 in Genome Data Viewer
    Location:
    2 B; 2 21.68 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30282261..30290539)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30392254..30400529)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene mitoguardin 2 Neighboring gene STARR-positive B cell enhancer ABC_E410 Neighboring gene carnitine acetyltransferase Neighboring gene protein phosphatase 2 protein activator Neighboring gene STARR-positive B cell enhancer ABC_E5903 Neighboring gene STARR-seq mESC enhancer starr_04096 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:30319437-30319638 Neighboring gene STARR-positive B cell enhancer ABC_E1584 Neighboring gene STARR-positive B cell enhancer ABC_E3367 Neighboring gene immediate early response 5-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane PubMed 

    General protein information

    Preferred Names
    dolichyldiphosphatase 1
    Names
    protein 2-23
    NP_001277437.1
    NP_001277438.1
    NP_065062.1
    XP_006498270.1
    XP_030107771.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290508.2NP_001277437.1  dolichyldiphosphatase 1 isoform b

      See identical proteins and their annotated locations for NP_001277437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS71022.1
      UniProtKB/TrEMBL
      A0A140T8S3
      Related
      ENSMUSP00000119478.3, ENSMUST00000123202.8
      Conserved Domains (1) summary
      cl00474
      Location:182
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
    2. NM_001290509.2NP_001277438.1  dolichyldiphosphatase 1 isoform c

      See identical proteins and their annotated locations for NP_001277438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS79768.1
      UniProtKB/TrEMBL
      A2AWJ3
      Related
      ENSMUSP00000109242.4, ENSMUST00000113612.10
      Conserved Domains (1) summary
      cd03382
      Location:16154
      PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...
    3. NM_020329.5NP_065062.1  dolichyldiphosphatase 1 isoform a

      See identical proteins and their annotated locations for NP_065062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS15881.1
      UniProtKB/Swiss-Prot
      Q8BN02, Q8R0P7, Q9CRF2, Q9JMF7
      Related
      ENSMUSP00000028209.9, ENSMUST00000028209.15
      Conserved Domains (2) summary
      COG0671
      Location:9184
      PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
      cd03382
      Location:16180
      PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...

    RNA

    1. NR_110963.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL954388
      Related
      ENSMUST00000137248.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30282261..30290539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498207.5XP_006498270.1  dolichyldiphosphatase 1 isoform X1

      See identical proteins and their annotated locations for XP_006498270.1

      UniProtKB/TrEMBL
      A0A140T8S3
      Conserved Domains (1) summary
      cl00474
      Location:182
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
    2. XM_030251911.2XP_030107771.1  dolichyldiphosphatase 1 isoform X1

      UniProtKB/TrEMBL
      A0A140T8S3
      Conserved Domains (1) summary
      cl00474
      Location:182
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
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