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    Toporsl topoisomerase I binding, arginine/serine-rich like [ Mus musculus (house mouse) ]

    Gene ID: 68274, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Toporslprovided by MGI
    Official Full Name
    topoisomerase I binding, arginine/serine-rich likeprovided by MGI
    Primary source
    MGI:MGI:1915524
    See related
    Ensembl:ENSMUSG00000028314 AllianceGenome:MGI:1915524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930547C10Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein monoubiquitination and protein polyubiquitination. Is expressed in ductus deferens; epididymis; esophagus; and testis. Orthologous to human TOPORSLP (topoisomerase I binding, arginine and serine rich like, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 15.4) See more
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    Genomic context

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    See Toporsl in Genome Data Viewer
    Location:
    4 B2; 4 28.4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (52596274..52612430)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (52596274..52612430)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10210 Neighboring gene Tmc4 retrotransposed pseudogene Neighboring gene structural maintenance of chromosomes 2 Neighboring gene VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene Neighboring gene STARR-seq mESC enhancer starr_10212 Neighboring gene STARR-seq mESC enhancer starr_10213 Neighboring gene predicted gene, 33435 Neighboring gene RIKEN cDNA 4930552N02 gene Neighboring gene nascent polypeptide-associated complex alpha polypeptide pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    topoisomerase I binding, arginine/serine-rich like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356293.1 → NP_001343222.1  topoisomerase I binding, arginine/serine-rich like

      Status: VALIDATED

      Source sequence(s)
      AK019748, AL732512, AL772233, AV041323, AV275899, BY715289
      Consensus CDS
      CCDS18182.1
      UniProtKB/TrEMBL
      Q9D2F8
      Related
      ENSMUSP00000103298.2, ENSMUST00000107671.2
      Conserved Domains (1) summary
      pfam15090
      Location:357 → 514
      DUF4553; Domain of unknown function (DUF4553)

    2. NM_026652.3 → NP_080928.1  topoisomerase I binding, arginine/serine-rich like

      See identical proteins and their annotated locations for NP_080928.1

      Status: VALIDATED

      Source sequence(s)
      AK019748, AL772233, AV041323, AV275899
      Consensus CDS
      CCDS18182.1
      UniProtKB/TrEMBL
      Q9D2F8
      Related
      ENSMUSP00000029995.6, ENSMUST00000029995.6
      Conserved Domains (1) summary
      pfam15090
      Location:357 → 514
      DUF4553; Domain of unknown function (DUF4553)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      52596274..52612430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538218.3 → XP_006538281.1  topoisomerase I binding, arginine/serine-rich like isoform X1

      See identical proteins and their annotated locations for XP_006538281.1

      UniProtKB/TrEMBL
      Q9D2F8
      Conserved Domains (1) summary
      pfam15090
      Location:357 → 514
      DUF4553; Domain of unknown function (DUF4553)

    2. XM_006538219.3 → XP_006538282.1  topoisomerase I binding, arginine/serine-rich like isoform X1

      See identical proteins and their annotated locations for XP_006538282.1

      UniProtKB/TrEMBL
      Q9D2F8
      Conserved Domains (1) summary
      pfam15090
      Location:357 → 514
      DUF4553; Domain of unknown function (DUF4553)
    Nucleotide Protein Strain
    Heading Accession and Version

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