Gbp3 guanylate binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gbp3provided by MGI
Official Full Name: guanylate binding protein 3provided by MGI
Primary source: MGI:MGI:1926263
See related: Ensembl:ENSMUSG00000028268 AllianceGenome:MGI:1926263
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gbp4; GBP-3; GBP-4
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of defense response; and response to bacterium. Acts upstream of or within adhesion of symbiont to host and defense response to other organism. Located in cytoplasmic vesicle; cytosol; and symbiont-containing vacuole membrane. Orthologous to human GBP4 (guanylate binding protein 4) and GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 10.8), subcutaneous fat pad adult (RPKM 6.0) and 21 other tissues See more
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Genomic context

Location:: 3 H1; 3 66.69 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (142265781..142278974)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (142560016..142573213)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis.
Title: Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis.
GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
Title: GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
GBP3 over-expression promotes glioma growth in mice and is inversely correlated with patients survival rate.
Title: GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW228655 (e-PCR)
- UniSTS:178945

U44731 (e-PCR)
- UniSTS:125753

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adhesion of symbiont to host	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in cytolysis in another organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to protozoan	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in symbiont-containing vacuole membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanylate-binding protein 3

Names: GTP-binding protein 3; GTP-binding protein 4; guanine nucleotide-binding protein 3; guanine nucleotide-binding protein 4; guanylate nucleotide binding protein 3; guanylate nucleotide binding protein 4; guanylate-binding protein 4; putative purine nucleotide binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289492.3 → NP_001276421.1 guanylate-binding protein 3

See identical proteins and their annotated locations for NP_001276421.1

Status: VALIDATED

Source sequence(s)

AC102108, AK132266, CK389037

Consensus CDS

CCDS17879.1

UniProtKB/Swiss-Prot

Q61107, Q8VEC5

Related

ENSMUSP00000029935.8, ENSMUST00000029935.14

Conserved Domains (2) summary

pfam02263
Location:12 → 275

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:277 → 573

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001289493.2 → NP_001276422.1 guanylate-binding protein 3

See identical proteins and their annotated locations for NP_001276422.1

Status: VALIDATED

Source sequence(s)

AC102108, AK132266, CK389037

Consensus CDS

CCDS17879.1

UniProtKB/Swiss-Prot

Q61107, Q8VEC5

Related

ENSMUSP00000101828.2, ENSMUST00000106221.8

Conserved Domains (2) summary

pfam02263
Location:12 → 275

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:277 → 573

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001355403.2 → NP_001342332.1 guanylate-binding protein 3

Status: VALIDATED

Source sequence(s)

AC102108

Consensus CDS

CCDS17879.1

UniProtKB/Swiss-Prot

Q61107, Q8VEC5

Conserved Domains (2) summary

pfam02263
Location:12 → 275

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:277 → 573

GBP_C; Guanylate-binding protein, C-terminal domain
NM_018734.4 → NP_061204.3 guanylate-binding protein 3

See identical proteins and their annotated locations for NP_061204.3

Status: VALIDATED

Source sequence(s)

AA162247, AC102108, AK132266

Consensus CDS

CCDS17879.1

UniProtKB/Swiss-Prot

Q61107, Q8VEC5

Related

ENSMUSP00000101829.3, ENSMUST00000106222.9

Conserved Domains (2) summary

pfam02263
Location:12 → 275

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:277 → 573

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

142265781..142278974

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501719.3 → XP_006501782.1 guanylate-binding protein 3 isoform X1

Conserved Domains (2) summary

pfam02263
Location:72 → 335

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:337 → 633

GBP_C; Guanylate-binding protein, C-terminal domain
XM_006501724.3 → XP_006501787.1 guanylate-binding protein 3 isoform X2

See identical proteins and their annotated locations for XP_006501787.1

UniProtKB/Swiss-Prot

Q61107, Q8VEC5

Conserved Domains (2) summary

pfam02263
Location:12 → 275

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:277 → 573

GBP_C; Guanylate-binding protein, C-terminal domain