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    Gpr34 G protein-coupled receptor 34 [ Mus musculus (house mouse) ]

    Gene ID: 23890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr34provided by MGI
    Official Full Name
    G protein-coupled receptor 34provided by MGI
    Primary source
    MGI:MGI:1346334
    See related
    Ensembl:ENSMUSG00000040229 AllianceGenome:MGI:1346334
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lypsr1
    Summary
    Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; liver; skeletal muscle tissue; spleen; and tongue. Orthologous to human GPR34 (G protein-coupled receptor 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 2.0), cortex adult (RPKM 2.0) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr34 in Genome Data Viewer
    Location:
    X A1.1; X 8.55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (13489777..13507098)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (13622650..13640859)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene nyctalopin Neighboring gene predicted gene 14506 Neighboring gene calcium/calmodulin dependent serine protein kinase Neighboring gene predicted gene, 34836 Neighboring gene G protein-coupled receptor 82 Neighboring gene nuclear encoded tRNA glutamine 1 (anticodon TTG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered immune response in mice deficient for the G protein-coupled receptor GPR34. Liebscher I, et al. J Biol Chem, 2011 Jan 21. PMID 21097509, Free PMC Article
    2. GPR34 in spinal microglia exacerbates neuropathic pain in mice. Sayo A, et al. J Neuroinflammation, 2019 Apr 11. PMID 30975169, Free PMC Article
    3. Dendritic Cells Regulate GPR34 through Mitogenic Signals and Undergo Apoptosis in Its Absence. Jäger E, et al. J Immunol, 2016 Mar 15. PMID 26851221
    4. GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity. Yan J, et al. Nat Immunol, 2024 Nov. PMID 39358444
    5. Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34. Sugihara R, et al. Nat Commun, 2023 Jul 31. PMID 37524709, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity.
      Title: GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity.
    2. GPR34 Knockdown Relieves Cognitive Deficits and Suppresses Neuroinflammation in Alzheimer's Disease via the ERK/NF-kappaB Signal.
      Title: GPR34 Knockdown Relieves Cognitive Deficits and Suppresses Neuroinflammation in Alzheimer's Disease via the ERK/NF-κB Signal.
    3. The Inhibition of GPR34-mediated signal by GPR34 gene deletion reduced nerve injury-induced neuropathic pain by suppressing pro-inflammatory responses of microglia without affecting their morphology.
      Title: GPR34 in spinal microglia exacerbates neuropathic pain in mice.
    4. Our study reveals a novel role of GPR34 in the fate of dendritic cells
      Title: Dendritic Cells Regulate GPR34 through Mitogenic Signals and Undergo Apoptosis in Its Absence.
    5. GPR34-deficient microglia showed reduced phagocytosis activity in both retina and acutely isolated cortical slices.
      Title: Altered microglial phagocytosis in GPR34-deficient mice.
    6. The present studies confirm that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position.
      Title: GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.
    7. GPR34-deficient mice showed significantly increased paw swelling in the delayed type hypersensitivity test and higher pathogen burden in extrapulmonary tissues after pulmonary infection with Cryptococcus neoformans compared with wild-type mice.
      Title: Altered immune response in mice deficient for the G protein-coupled receptor GPR34.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 34
    Names
    G-protein-coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011823.5 → NP_035953.3  probable G-protein coupled receptor 34

      See identical proteins and their annotated locations for NP_035953.3

      Status: VALIDATED

      Source sequence(s)
      AL671117
      Consensus CDS
      CCDS30028.1
      UniProtKB/Swiss-Prot
      Q9R1K6
      UniProtKB/TrEMBL
      Q3YL73, Q8BYI1
      Related
      ENSMUSP00000042715.4, ENSMUST00000041708.10
      Conserved Domains (1) summary
      cd15148
      Location:48 → 331
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      13489777..13507098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527625.5 → XP_006527688.1  probable G-protein coupled receptor 34 isoform X1

      See identical proteins and their annotated locations for XP_006527688.1

      UniProtKB/Swiss-Prot
      Q9R1K6
      UniProtKB/TrEMBL
      Q3YL73, Q8BYI1
      Related
      ENSMUSP00000094236.4, ENSMUST00000096492.4
      Conserved Domains (1) summary
      cd15148
      Location:48 → 331
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_036161948.1 → XP_036017841.1  probable G-protein coupled receptor 34 isoform X1

      UniProtKB/Swiss-Prot
      Q9R1K6
      UniProtKB/TrEMBL
      Q3YL73, Q8BYI1
      Conserved Domains (1) summary
      cd15148
      Location:48 → 331
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_036161949.1 → XP_036017842.1  probable G-protein coupled receptor 34 isoform X1

      UniProtKB/Swiss-Prot
      Q9R1K6
      UniProtKB/TrEMBL
      Q3YL73, Q8BYI1
      Conserved Domains (1) summary
      cd15148
      Location:48 → 331
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1K6.1 GenPept UniProtKB/Swiss-Prot:Q9R1K6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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