Hvcn1 hydrogen voltage-gated channel 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hvcn1provided by MGI
Official Full Name: hydrogen voltage-gated channel 1provided by MGI
Primary source: MGI:MGI:1921346
See related: Ensembl:ENSMUSG00000064267 AllianceGenome:MGI:1921346
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BTS; HV1; Vsop.; mVSOP; 0610039P13Rik
Summary: Enables protein homodimerization activity and voltage-gated proton channel activity. Involved in several processes, including proton transmembrane transport; regulation of reactive oxygen species biosynthetic process; and response to zinc ion. Located in phagocytic vesicle membrane. Orthologous to human HVCN1 (hydrogen voltage gated channel 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 61.0), mammary gland adult (RPKM 25.5) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.23 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (122344872..122380360)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122206805..122242297)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results indicate that dextromethorphan inhibition of proton currents would suppress NADPH oxidase activity and, eventually, microglial activation.
Title: Dextromethorphan inhibition of voltage-gated proton currents in BV2 microglial cells.
the protective effects of Hv1 deficiency on oligodendrocyte precursor cell are due to the suppression of reactive oxygen species and pro-inflammatory cytokine production in microglia.
Title: Hv1 proton channel facilitates production of ROS and pro-inflammatory cytokines in microglia and enhances oligodendrocyte progenitor cells damage from oxygen-glucose deprivation in vitro.
Loss of the voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice.
Title: Loss of the voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice.
Regulation of hepatic oxidative stress by voltage-gated proton channels (Hv1/VSOP) in Kupffer cells and its potential relationship with glucose metabolism.
Title: Regulation of hepatic oxidative stress by voltage-gated proton channels (Hv1/VSOP) in Kupffer cells and its potential relationship with glucose metabolism.
The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury.
Title: The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury.
Voltage-Gated Proton Channel Hv1 Controls TLR9 Activation in Plasmacytoid Dendritic Cells.
Title: Voltage-Gated Proton Channel Hv1 Controls TLR9 Activation in Plasmacytoid Dendritic Cells.
Knockout of microglial Hv1 proton channel reduces neurotoxic A1 astrocytes and neuronal damage via the ROS/STAT3 pathway after spinal cord injury.
Title: Knockout of microglial Hv1 proton channel reduces neurotoxic A1 astrocytes and neuronal damage via the ROS/STAT3 pathway after spinal cord injury.
The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the Hv1.
Title: The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1.
Expression of Hv1 proton channels in myeloid-derived suppressor cells (MDSC) and its potential role in T cell regulation.
Title: Expression of H(v)1 proton channels in myeloid-derived suppressor cells (MDSC) and its potential role in T cell regulation.
The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury.
Title: The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235304

AI450555 (e-PCR)
- UniSTS:159441

BE457402 (e-PCR)
- UniSTS:207871

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated proton channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated proton channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated proton channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of acrosome reaction	IEA Inferred from Electronic Annotation more info
involved_in regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed
involved_in response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to zinc ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: voltage-gated hydrogen channel 1

Names: voltage sensor domain-only protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042489.2 → NP_001035954.1 voltage-gated hydrogen channel 1

See identical proteins and their annotated locations for NP_001035954.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AC127266, AK002854, CF734112, CF749152

Consensus CDS

CCDS19644.1

UniProtKB/Swiss-Prot

Q3U2S8, Q9DCE4

Related

ENSMUSP00000072401.8, ENSMUST00000072602.14

Conserved Domains (2) summary

pfam16799
Location:222 → 269

VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1

pfam00520
Location:125 → 191

Ion_trans; Ion transport protein
NM_001359454.1 → NP_001346383.1 voltage-gated hydrogen channel 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC127266

Consensus CDS

CCDS19644.1

UniProtKB/Swiss-Prot

Q3U2S8, Q9DCE4

Conserved Domains (2) summary

pfam16799
Location:222 → 269

VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1

pfam00520
Location:125 → 191

Ion_trans; Ion transport protein
NM_028752.3 → NP_083028.1 voltage-gated hydrogen channel 1

See identical proteins and their annotated locations for NP_083028.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC127266, AK002854

Consensus CDS

CCDS19644.1

UniProtKB/Swiss-Prot

Q3U2S8, Q9DCE4

Related

ENSMUSP00000098312.3, ENSMUST00000100747.3

Conserved Domains (2) summary

pfam16799
Location:222 → 269

VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1

pfam00520
Location:125 → 191

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

122344872..122380360

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530472.4 → XP_006530535.1 voltage-gated hydrogen channel 1 isoform X2

See identical proteins and their annotated locations for XP_006530535.1

UniProtKB/Swiss-Prot

Q3U2S8, Q9DCE4

Conserved Domains (2) summary

pfam16799
Location:222 → 269

VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1

pfam00520
Location:125 → 191

Ion_trans; Ion transport protein
XM_006530471.5 → XP_006530534.1 voltage-gated hydrogen channel 1 isoform X1

Conserved Domains (2) summary

pfam16799
Location:226 → 273

VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1

pfam00520
Location:129 → 195

Ion_trans; Ion transport protein