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    ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 6482, updated on 10-Dec-2024

    Summary

    Official Symbol
    ST3GAL1provided by HGNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:10862
    See related
    Ensembl:ENSG00000008513 MIM:607187; AllianceGenome:HGNC:10862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST3O; SIAT4A; SIATFL; ST3GalA; ST3GalIA; Gal-NAc6S; ST3GalA.1; ST3GalIA,1
    Summary
    The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 30.7), kidney (RPKM 13.0) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ST3GAL1 in Genome Data Viewer
    Location:
    8q24.22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (133454848..133571887, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (134578690..134699857, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (134467091..134584130, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134420089-134420640 Neighboring gene DPPA3 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134434961-134435460 Neighboring gene ST13, Hsp70 interacting protein pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:134461533-134461691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19563 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134465210-134465710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134465711-134466211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134500724-134501507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134502985-134503530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134512049-134512574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134513872-134514372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28003 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:134544558-134545408 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134581917-134582770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19566 Neighboring gene ST3GAL1 divergent transcript Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101278 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:134643666-134643864 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene long intergenic non-protein coding RNA 3024

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (59 hits/1264 screens)

    EBI GWAS Catalog

    Description
    Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
    EBI GWAS Catalog
    Genome-wide association study and meta-analysis of intraocular pressure.
    EBI GWAS Catalog
    Genome-wide association study of the five-factor model of personality in young Korean women.
    EBI GWAS Catalog
    Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC9183, FLJ36548, DKFZp666E036, DKFZp779K2051

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in N-acetylneuraminate metabolic process  
    involved_in O-glycan processing  
    involved_in ganglioside biosynthetic process via lactosylceramide  
    involved_in ganglioside biosynthetic process via lactosylceramide PubMed 
    involved_in keratan sulfate biosynthetic process  
    involved_in memory B cell differentiation  
    involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process  
    involved_in protein N-linked glycosylation  
    involved_in protein glycosylation  
    involved_in protein modification process PubMed 
    involved_in protein sialylation PubMed 
    involved_in sialylation  
    involved_in sialylation  
    involved_in viral protein processing  

    General protein information

    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
    Names
    Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    SIAT4-A
    ST3GalI
    alpha 2,3-ST 1
    beta-galactoside alpha-2,3-sialyltransferase 1
    monosialoganglioside sialyltransferase
    sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
    sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase)
    sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
    NP_003024.1
    NP_775479.1
    XP_005251082.1
    XP_006716680.1
    XP_016869225.1
    XP_047278061.1
    XP_047278062.1
    XP_054216992.1
    XP_054216993.1
    XP_054216994.1
    XP_054216995.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003033.4 → NP_003024.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

      See identical proteins and their annotated locations for NP_003024.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF186191, BC018357, BX648001
      Consensus CDS
      CCDS6373.1
      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Related
      ENSP00000428540.1, ENST00000521180.5
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. NM_173344.3 → NP_775479.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

      See identical proteins and their annotated locations for NP_775479.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF059321, AF186191, BC018357, BX648001, CN359425
      Consensus CDS
      CCDS6373.1
      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Related
      ENSP00000430515.1, ENST00000522652.6
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      133454848..133571887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013736.3 → XP_016869225.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. XM_006716617.3 → XP_006716680.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006716680.1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Related
      ENSP00000497381.1, ENST00000648219.1
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    3. XM_047422106.1 → XP_047278062.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
    4. XM_047422105.1 → XP_047278061.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
    5. XM_005251025.6 → XP_005251082.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005251082.1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      134578690..134699857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361018.1 → XP_054216993.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
    2. XM_054361017.1 → XP_054216992.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
    3. XM_054361020.1 → XP_054216995.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
    4. XM_054361019.1 → XP_054216994.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O60677, Q11201, Q9UN51
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