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    PABPN1L PABPN1 like, cytoplasmic [ Homo sapiens (human) ]

    Gene ID: 390748, updated on 10-Dec-2024

    Summary

    Official Symbol
    PABPN1Lprovided by HGNC
    Official Full Name
    PABPN1 like, cytoplasmicprovided by HGNC
    Primary source
    HGNC:HGNC:37237
    See related
    Ensembl:ENSG00000205022 AllianceGenome:HGNC:37237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ePABP2; PABPNL1
    Summary
    Predicted to enable poly(A) binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to act upstream of or within maternal-to-zygotic transition of gene expression; negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process; and negative regulation of protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 3.9), testis (RPKM 3.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PABPN1L in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (88863333..88870135, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (94933691..94940493, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88929741..88933068, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88876670-88877205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88878711-88879395 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88879396-88880079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88882597-88883098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88883099-88883598 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:88884193-88885392 Neighboring gene adenine phosphoribosyltransferase Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7882 Neighboring gene uncharacterized LOC107983950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7883 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88930168-88930918 Neighboring gene trafficking protein particle complex subunit 2L Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11373 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:88940900-88941052 Neighboring gene uncharacterized LOC101927793 Neighboring gene CBFA2/RUNX1 partner transcriptional co-repressor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88958623-88959123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88968733-88969276 Neighboring gene uncharacterized LOC102724632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7884

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    embryonic polyadenylate-binding protein 2
    Names
    ePABP-2
    embryonic poly(A)-binding protein 2
    embryonic poly(A)-binding protein type II
    poly(A) binding protein nuclear 1 like, cytoplasmic
    poly(A)-binding protein nuclear-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080487.4NP_001073956.2  embryonic polyadenylate-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001073956.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC092384
      Consensus CDS
      CCDS45547.2
      UniProtKB/Swiss-Prot
      A1L3B3, A2VDI2, A6NDY0
      UniProtKB/TrEMBL
      B6RF28
      Related
      ENSP00000408598.2, ENST00000419291.7
      Conserved Domains (2) summary
      COG0724
      Location:138231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12551
      Location:148224
      RRM_II_PABPN1L; RNA recognition motif in vertebrate type II embryonic polyadenylate-binding protein 2 (ePABP-2)
    2. NM_001294328.4NP_001281257.1  embryonic polyadenylate-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001281257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC092384
      Consensus CDS
      CCDS73925.1
      UniProtKB/Swiss-Prot
      A6NDY0
      Related
      ENSP00000405259.2, ENST00000411789.6
      Conserved Domains (2) summary
      COG0724
      Location:138191
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:148189
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001385709.2NP_001372638.1  embryonic polyadenylate-binding protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AC092384
      UniProtKB/TrEMBL
      A0A1C7CYY8
      Related
      ENSP00000449247.1, ENST00000547152.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      88863333..88870135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434103.1XP_047290059.1  embryonic polyadenylate-binding protein 2 isoform X2

    2. XM_047434102.1XP_047290058.1  embryonic polyadenylate-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A1L3B3, A2VDI2, A6NDY0
      UniProtKB/TrEMBL
      B6RF28

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      94933691..94940493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380318.1XP_054236293.1  embryonic polyadenylate-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      B6RF28