XACT X active specific transcript [Homo sapiens (human)] - Gene

Summary

Official Symbol: XACTprovided by HGNC
Official Full Name: X active specific transcriptprovided by HGNC
Primary source: HGNC:HGNC:45056
See related: MIM:300901; AllianceGenome:HGNC:45056
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene produces a spliced long non-coding RNA that is thought to play a role in the control of X-chromosome inactivation (XCI). This transcript has been shown to specifically coat the active X chromosome in human pluripotent cells. [provided by RefSeq, Mar 2015]
Annotation information: Annotation category: partial on reference assembly
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: Xq23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (113616300..113618153, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (112069011..112070863, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (112859587..112861440, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The endogenous retroviruses was hijacked by younger hominoid-specific endogenous retroviruses that gave rise to the promoter of XACT, thus wiring its expression to the pluripotency network.
Title: A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans.
These findings therefore suggest a mechanism involving antagonistic activity of XIST and XACT in controlling X chromosome activity in early human embryos.
Title: XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development.
XACT is a novel lncRNA that coats the active X-chromosome specifically in human pluripotent cells highlighting the existence of human-specific mechanisms of X-chromosome regulation.
Title: Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

X active coating transcript
X active specific transcript (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.