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    TUBE1 tubulin epsilon 1 [ Homo sapiens (human) ]

    Gene ID: 51175, updated on 10-Dec-2024

    Summary

    Official Symbol
    TUBE1provided by HGNC
    Official Full Name
    tubulin epsilon 1provided by HGNC
    Primary source
    HGNC:HGNC:20775
    See related
    Ensembl:ENSG00000074935 MIM:607345; AllianceGenome:HGNC:20775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TUBE; dJ142L7.2
    Summary
    This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]
    Expression
    Broad expression in testis (RPKM 21.9), endometrium (RPKM 10.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TUBE1 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (112070663..112087482, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (113254081..113270900, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (112391866..112408685, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24958 Neighboring gene Sharpr-MPRA regulatory region 11311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17484 Neighboring gene cellular communication network factor 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:112408399-112408930 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:112421446-112422235 Neighboring gene family with sequence similarity 229 member B Neighboring gene MPRA-validated peak6040 silencer Neighboring gene MPRA-validated peak6041 silencer Neighboring gene uncharacterized LOC107986633 Neighboring gene laminin subunit alpha 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:112462018-112463217

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
    tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ22589, FLJ44203

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding  
    enables structural constituent of cytoskeleton  
    Process Evidence Code Pubs
    involved_in centrosome cycle PubMed 
    involved_in microtubule cytoskeleton organization  
    involved_in mitotic cell cycle  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in microtubule  
    located_in pericentriolar material PubMed 

    General protein information

    Preferred Names
    tubulin epsilon chain
    Names
    epsilon-tubulin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016262.5NP_057346.1  tubulin epsilon chain

      See identical proteins and their annotated locations for NP_057346.1

      Status: REVIEWED

      Source sequence(s)
      AK026242, BC025405, CA411886
      Consensus CDS
      CCDS5100.1
      UniProtKB/Swiss-Prot
      Q5H8W8, Q8NEG3, Q9UJT0
      Related
      ENSP00000357651.5, ENST00000368662.10
      Conserved Domains (1) summary
      cd02190
      Location:2457
      epsilon_tubulin; The epsilon-tubulin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      112070663..112087482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418855.1XP_047274811.1  tubulin epsilon chain isoform X2

    2. XM_047418854.1XP_047274810.1  tubulin epsilon chain isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      113254081..113270900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355563.1XP_054211538.1  tubulin epsilon chain isoform X2

    2. XM_054355562.1XP_054211537.1  tubulin epsilon chain isoform X1

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