RNU11 RNA, U11 small nuclear [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNU11provided by HGNC
Official Full Name: RNA, U11 small nuclearprovided by HGNC
Primary source: HGNC:HGNC:10108
See related: Ensembl:ENSG00000274978 AllianceGenome:HGNC:10108
Gene type: snRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: U11; RNU11-1
Summary: Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA 5'-splice site recognition. Predicted to act upstream of or within RNA splicing. Predicted to be part of U11 snRNP. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 1p35.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (28648600..28648734)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (28490564..28490698)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (28975112..28975246)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High serum level of U11snRNA correlate with autoimmune diseases in human subjects. U11snRNA contains sequences, particularly in the SM region, which fulfill a known criterion as a TLR7 agonist ligand, namely a U-rich sequence together with a G residue(s).
Title: Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.
Ribosomal protein eS1 is engaged in cellular events related to processing and functioning of U11 snRNA.
Title: Human ribosomal protein eS1 is engaged in cellular events related to processing and functioning of U11 snRNA.
conclude that U11 functions not only in 5'ss recognition in constitutive splicing, but also as an activator of U2-dependent alternative splicing and as a regulator of the U12-dependent spliceosome.
Title: An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables pre-mRNA 5'-splice site binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA 5'-splice site recognition	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U11 snRNP	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.