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    SRP14 signal recognition particle 14 [ Homo sapiens (human) ]

    Gene ID: 6727, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SRP14provided by HGNC
    Official Full Name
    signal recognition particle 14provided by HGNC
    Primary source
    HGNC:HGNC:11299
    See related
    Ensembl:ENSG00000140319 MIM:600708; AllianceGenome:HGNC:11299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALURBP
    Summary
    Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 125.3), adrenal (RPKM 118.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SRP14 in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40035690..40039202, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (37841027..37844472, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40327891..40331403, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40251723-40252224 Neighboring gene H3 histone pseudogene 38 Neighboring gene Sharpr-MPRA regulatory region 10520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40314575-40315076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40315077-40315576 Neighboring gene uncharacterized LOC124903471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40330400-40331345 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40331346-40332290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9222 Neighboring gene SRP14 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40347031-40347610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40354716-40355551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9228 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40360521-40360704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9229 Neighboring gene uncharacterized LOC105370787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40369263-40369763

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of signal recognition particle 14 in hepatocellular carcinoma and its relationship with disease progression and patient survival. Tian H, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2024 Aug 25. PMID 39183055, Free PMC Article
    2. The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. Bovia F, et al. Mol Biol Cell, 1995 Apr. PMID 7542942, Free PMC Article
    3. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. Chang DY, et al. Mol Cell Biol, 1994 Jun. PMID 8196634, Free PMC Article
    4. SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites. Lakkaraju AK, et al. Cell, 2008 May 2. PMID 18455985, Free PMC Article
    5. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Strub K, et al. Mol Cell Biol, 1990 Feb. PMID 2153922, Free PMC Article

    See all (176) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of signal recognition particle 14 in hepatocellular carcinoma and its relationship with disease progression and patient survival.
      Title: Expression of signal recognition particle 14 in hepatocellular carcinoma and its relationship with disease progression and patient survival.
    2. Dats show that Alu RNA promotes functional binding of Signal Recognition Particle proteins SRP9/14 to 40S ribosomal subunits.
      Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits.
    3. mutational study on SRP9/14 that identified and characterized regions and single residues essential for elongation arrest activity
      Title: Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein.
    4. SRP14 mutant proteins with absence of a peptide elongation delay caused inefficient targeting of preproteins leading to defects in secretion, depletion of proteins in the endogenous membranes, and reduced cell growth.
      Title: SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with signal recognition particle 14kDa (SRP14, homologous Alu RNA binding protein) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of signal recognition particle 14kDa (SRP14) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC14326

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables endoplasmic reticulum signal peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cotranslational protein targeting to membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal recognition particle 14 kDa protein
    Names
    18 kDa Alu RNA-binding protein
    homologous Alu RNA binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309434.1 → NP_001296363.1  signal recognition particle 14 kDa protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in its 5' coding region, which results in a frameshift and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to variant 1.
      Source sequence(s)
      AC025168, BC051006, DA338824
      Conserved Domains (1) summary
      pfam02290
      Location:23 → 46
      SRP14; Signal recognition particle 14kD protein

    2. NM_003134.6 → NP_003125.3  signal recognition particle 14 kDa protein isoform 1

      See identical proteins and their annotated locations for NP_003125.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC035495, CV575824, DA338824
      Consensus CDS
      CCDS42017.1
      UniProtKB/Swiss-Prot
      B5BUF5, P37108, Q6B0K5, Q96Q14
      Related
      ENSP00000267884.6, ENST00000267884.11
      Conserved Domains (1) summary
      pfam02290
      Location:4 → 94
      SRP14; Signal recognition particle 14kD protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      40035690..40039202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      37841027..37844472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37108.2 GenPept UniProtKB/Swiss-Prot:P37108

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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