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    DECR2 2,4-dienoyl-CoA reductase 2 [ Homo sapiens (human) ]

    Gene ID: 26063, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DECR2provided by HGNC
    Official Full Name
    2,4-dienoyl-CoA reductase 2provided by HGNC
    Primary source
    HGNC:HGNC:2754
    See related
    Ensembl:ENSG00000242612 MIM:615839; AllianceGenome:HGNC:2754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDCR; SDR17C1
    Summary
    Enables 2,4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in cytosol and peroxisomal membrane. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney (RPKM 18.7), liver (RPKM 15.2) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See DECR2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (401885..412482)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (398130..408668)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (451885..462482)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100134368 Neighboring gene post-GPI attachment to proteins 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:440484-440661 Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:449109-449694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:450865-451450 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene RAB11 family interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:492123-492661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495322-495822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495823-496323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516240-516869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516870-517498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:532003-532508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:534533-535038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:535039-535544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:537093-537971 Neighboring gene uncharacterized LOC107987417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:542303-542924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:544383-544961 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:544962-545539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:576271-576832 Neighboring gene long intergenic non-protein coding RNA 235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer. Mah CY, et al. Br J Cancer, 2024 Mar. PMID 38216720, Free PMC Article
    2. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. De Nys K, et al. Biochim Biophys Acta, 2001 Aug 29. PMID 11514237
    3. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. Das AK, et al. J Biol Chem, 2000 Aug 11. PMID 10811639
    4. Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells. Okumoto K, et al. Subcell Biochem, 2018. PMID 30378028
    5. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix. Okumoto K, et al. J Biol Chem, 2011 Dec 30. PMID 22002062, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peroxisomal beta-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer.
      Title: Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: NME4

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables trans-2-enoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables trans-2-enoyl-CoA reductase (NADPH) activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase TAS
    Traceable Author Statement
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in peroxisomal membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
    Names
    2,4-dienoyl-CoA reductase 2, peroxisomal
    peroxisomal 2,4-dienoyl-CoA reductase
    short chain dehydrogenase/reductase family 17C member 1
    NP_065715.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020664.4 → NP_065715.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

      See identical proteins and their annotated locations for NP_065715.1

      Status: VALIDATED

      Source sequence(s)
      BC010740, BC030226
      Consensus CDS
      CCDS10409.1
      UniProtKB/Swiss-Prot
      Q6ZRS7, Q96ET0, Q9NUI1
      UniProtKB/TrEMBL
      Q4VXZ8
      Related
      ENSP00000219481.5, ENST00000219481.10
      Conserved Domains (1) summary
      cd05369
      Location:26 → 273
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      401885..412482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187610.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1031..11628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      398130..408668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NUI1.1 GenPept UniProtKB/Swiss-Prot:Q9NUI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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