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    NCOA1 nuclear receptor coactivator 1 [ Homo sapiens (human) ]

    Gene ID: 8648, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NCOA1provided by HGNC
    Official Full Name
    nuclear receptor coactivator 1provided by HGNC
    Primary source
    HGNC:HGNC:7668
    See related
    Ensembl:ENSG00000084676 MIM:602691; AllianceGenome:HGNC:7668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74
    Summary
    The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 17.5), testis (RPKM 14.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NCOA1 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24491254..24770702)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24525913..24805480)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24714123..24993571)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene intersectin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15432 Neighboring gene ribosomal protein L36a pseudogene 13 Neighboring gene Sharpr-MPRA regulatory region 9937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:24623030-24623530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24625230-24625736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24625737-24626243 Neighboring gene uncharacterized LOC105374329 Neighboring gene NANOG hESC enhancer GRCh37_chr2:24679828-24680425 Neighboring gene CRISPRi-validated cis-regulatory element chr2.904 Neighboring gene Sharpr-MPRA regulatory region 4589 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:24714093-24714251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11232 Neighboring gene MPRA-validated peak3621 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15433 Neighboring gene RNA, 5S ribosomal pseudogene 88 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15434 Neighboring gene RNA, U6 small nuclear 936, pseudogene Neighboring gene uncharacterized LOC105369164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25044835-25045378 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene centromere protein O Neighboring gene adenylate cyclase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities. Cacciottolo TM, et al. J Clin Endocrinol Metab, 2022 May 17. PMID 35137184, Free PMC Article
    2. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. Onate SA, et al. J Biol Chem, 1998 May 15. PMID 9575154
    3. The receptor-associated coactivator 3 activates transcription through CREB-binding protein recruitment and autoregulation. Li H, et al. J Biol Chem, 1998 Mar 6. PMID 9488734
    4. E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complex. Xu Y, et al. Mol Cell Biol, 2000 Mar. PMID 10688660, Free PMC Article
    5. Steroid receptor coactivator-1 enhances the stemness of glioblastoma by activating long noncoding RNA XIST/miR-152/KLF4 pathway. Gong M, et al. Cancer Sci, 2021 Feb. PMID 33090636, Free PMC Article

    See all (349) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP-9.
      Title: Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP-9.
    2. Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma.
      Title: Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma.
    3. Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities.
      Title: Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities.
    4. Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling.
      Title: Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling.
    5. PRRX1-NCOA1-rearranged fibroblastic tumour: a clinicopathological, immunohistochemical and molecular genetic study of six cases of a potentially under-recognised, distinctive mesenchymal tumour.
      Title: PRRX1-NCOA1-rearranged fibroblastic tumour: a clinicopathological, immunohistochemical and molecular genetic study of six cases of a potentially under-recognised, distinctive mesenchymal tumour.
    6. Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
      Title: Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
    7. Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts.
      Title: Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts.
    8. A mutant form of ERalpha associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.
      Title: A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.
    9. Steroid receptor coactivator-1 enhances the stemness of glioblastoma by activating long noncoding RNA XIST/miR-152/KLF4 pathway.
      Title: Steroid receptor coactivator-1 enhances the stemness of glioblastoma by activating long noncoding RNA XIST/miR-152/KLF4 pathway.
    10. SRF-FOXO1 and SRF-NCOA1 gene fusion occurs in a subset of well differentiated rhabdomyosarcoma of the neck muscles.
      Title: SRF-FOXO1 and SRF-NCOA1 Fusion Genes Delineate a Distinctive Subset of Well-differentiated Rhabdomyosarcoma.
    Submit: New GeneRIF Correction See all GeneRIFs (87)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
    tat HIV-1 Tat-induced calcium mobilization and TNF-alpha production in primary human monocytes are entirely regulated by DHP receptors PubMed
    tat SRC1a binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
    Vpr vpr HIV-1 Vpr synergistically enhances SRC-1 ligand activated glucocorticoid receptor activity, however Vpr does not bind to SRC-1 PubMed
    matrix gag HIV-1 MA upregulates NCOA1 gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129719, MGC129720

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear retinoid X receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to Thyroglobulin triiodothyronine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in estrous cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hypothalamus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in labyrinthine layer morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male mating behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome proliferator activated receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of adipose tissue development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of female receptivity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription from RNA polymerase II promoter by galactose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in progesterone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cellular response to insulin stimulus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of thyroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor coactivator 1
    Names
    Hin-2 protein
    class E basic helix-loop-helix protein 74
    renal carcinoma antigen NY-REN-52
    steroid receptor coactivator-1
    NP_001349879.1
    NP_001349881.1
    NP_001349883.1
    NP_001349884.1
    NP_003734.3
    NP_671756.1
    NP_671766.1
    XP_047302107.1
    XP_047302108.1
    XP_047302109.1
    XP_047302110.1
    XP_047302111.1
    XP_047302112.1
    XP_047302113.1
    XP_047302114.1
    XP_054200298.1
    XP_054200299.1
    XP_054200300.1
    XP_054200301.1
    XP_054200302.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029014.2 RefSeqGene

      Range
      4205..283653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001362950.1 → NP_001349879.1  nuclear receptor coactivator 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013459, AC093798
      Consensus CDS
      CCDS1713.1
      UniProtKB/TrEMBL
      A8K1V4
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1149 → 1205
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1309
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    2. NM_001362952.1 → NP_001349881.1  nuclear receptor coactivator 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013459, AC093798
      Consensus CDS
      CCDS1713.1
      UniProtKB/TrEMBL
      A8K1V4
      Related
      ENSP00000385097.1, ENST00000405141.5
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1149 → 1205
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1309
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    3. NM_001362954.1 → NP_001349883.1  nuclear receptor coactivator 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013459, AC093798
      Consensus CDS
      CCDS1713.1
      UniProtKB/TrEMBL
      A8K1V4
      Related
      ENSP00000385195.1, ENST00000407230.5
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1149 → 1205
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1309
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    4. NM_001362955.1 → NP_001349884.1  nuclear receptor coactivator 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013459, AC093798
      Consensus CDS
      CCDS1713.1
      UniProtKB/TrEMBL
      A8K1V4
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1149 → 1205
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1309
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    5. NM_003743.5 → NP_003734.3  nuclear receptor coactivator 1 isoform 1

      See identical proteins and their annotated locations for NP_003734.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as SRC1a, encodes the longest isoform (1).
      Source sequence(s)
      AC013459, AC093798
      Consensus CDS
      CCDS1712.1
      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4
      Related
      ENSP00000320940.5, ENST00000348332.8
      Conserved Domains (10) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam09606
      Location:961 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam00989
      Location:116 → 173
      PAS; PAS fold
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    6. NM_147223.3 → NP_671756.1  nuclear receptor coactivator 1 isoform 2

      See identical proteins and their annotated locations for NP_671756.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as SRC1e, contains an additional segment in the coding region compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC013459, AC093798
      Consensus CDS
      CCDS1713.1
      UniProtKB/TrEMBL
      A8K1V4
      Related
      ENSP00000288599.5, ENST00000288599.9
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1149 → 1205
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1309
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    7. NM_147233.2 → NP_671766.1  nuclear receptor coactivator 1 isoform 3

      See identical proteins and their annotated locations for NP_671766.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as SRC(-Q), uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 3) that lacks a single amino acid, compared to isoform 1.
      Source sequence(s)
      AC013459, AJ000881, BE675986, BF975824, CB047008, U90661
      Consensus CDS
      CCDS42660.1
      UniProtKB/TrEMBL
      A8K1V4
      Related
      ENSP00000379197.3, ENST00000395856.3
      Conserved Domains (10) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam09606
      Location:961 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam00989
      Location:116 → 173
      PAS; PAS fold
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      24491254..24770702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446155.1 → XP_047302111.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    2. XM_047446156.1 → XP_047302112.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    3. XM_047446151.1 → XP_047302107.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    4. XM_047446157.1 → XP_047302113.1  nuclear receptor coactivator 1 isoform X2

      UniProtKB/TrEMBL
      A8K1V4

    5. XM_047446158.1 → XP_047302114.1  nuclear receptor coactivator 1 isoform X3

      UniProtKB/TrEMBL
      A8K1V4

    6. XM_047446154.1 → XP_047302110.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    7. XM_047446153.1 → XP_047302109.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    8. XM_047446152.1 → XP_047302108.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      24525913..24805480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344326.1 → XP_054200301.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    2. XM_054344323.1 → XP_054200298.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    3. XM_054344325.1 → XP_054200300.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    4. XM_054344324.1 → XP_054200299.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/Swiss-Prot
      O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
      UniProtKB/TrEMBL
      A8K1V4

    5. XM_054344327.1 → XP_054200302.1  nuclear receptor coactivator 1 isoform X3

      UniProtKB/TrEMBL
      A8K1V4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15788.3 GenPept UniProtKB/Swiss-Prot:Q15788

    Gene LinkOut

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