Trpv5 transient receptor potential cation channel, subfamily V, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpv5provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily V, member 5provided by MGI
Primary source: MGI:MGI:2429764
See related: Ensembl:ENSMUSG00000036899 AllianceGenome:MGI:2429764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAT2; ECAC1; D630033B11
Summary: Enables calcium channel activity. Involved in calcium ion homeostasis; calcium ion transmembrane transport; and regulation of urine volume. Located in apical plasma membrane. Part of calcium channel complex. Is expressed in central nervous system; metanephros; and sensory organ. Orthologous to human TRPV5 (transient receptor potential cation channel subfamily V member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 1.9), placenta adult (RPKM 0.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.1; 6 19.83 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (41628595..41658158, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (41651661..41681224, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NF-kappaB plays an important role in the transcriptional activation of estrogen-ERalpha stimulated TRPV5 expression to inhibit bone resorption and osteoclastogenesis.
Title: Regulation of TRPV5 transcription and expression by E2/ERα signalling contributes to inhibition of osteoclastogenesis.
This study found that TRPV5 and TRPV6 are involved in calcium transport in the placenta and bone, and therefore play a role in calcium homeostasis during embryonic and fetal development.
Title: TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.
life-long challenge of Ca2+ homeostasis present in Trpv5-/- mice causes accelerated bone aging and a low cortical and trabecular bone mass phenotype
Title: Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.
beta-gal is present in the pro-urine from where it is thought to stimulate TRPV5 activity.
Title: Urinary β-galactosidase stimulates Ca2+ transport by stabilizing TRPV5 at the plasma membrane.
A novel primary cell model with TRPV5-dependent Ca(2+) transport characteristics was successfully established.
Title: Coordinated regulation of TRPV5-mediated Ca²⁺ transport in primary distal convolution cultures.
Phosphorylation of beta1-AR by PKA stimulates active Ca(2+)influx through TRPV5.
Title: β1-Adrenergic receptor signaling activates the epithelial calcium channel, transient receptor potential vanilloid type 5 (TRPV5), via the protein kinase A pathway.
The expression of TRPV5 channel is regulated by estrogen via estrogen receptor in osteoblasts.
Title: Estrogen inhibits RANKL-induced osteoclastic differentiation by increasing the expression of TRPV5 channel.
Uromodulin upregulates TRPV5 by decreasing caveolin-1 dependent endocytosis of TRPV5.
Title: Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.
In colitis in mice, tumor necrosis factor and interferon-gamma reduced expression of Klotho, which otherwise would protect TRPV5 from hypersialylation and cytokine-induced TRPV5 endocytosis, UBR4-dependent ubiquitination, degradation, and Ca(2+) wasting.
Title: Post-translational loss of renal TRPV5 calcium channel expression, Ca(2+) wasting, and bone loss in experimental colitis.
The TRPV5 S682P mutant is a functionally significant factor in autosomal dominant hypercalciuria.
Title: Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpv5 (e-PCR), detects polymorphism
- UniSTS:531258

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport into cytosol	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	NAS Non-traceable Author Statement more info	PubMed
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily V member 5

Names: OTRPC3; calcium transport protein 2; epithelial calcium channel 1; osm-9-like TRP channel 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007572.2 → NP_001007573.1 transient receptor potential cation channel subfamily V member 5

See identical proteins and their annotated locations for NP_001007573.1

Status: PROVISIONAL

Source sequence(s)

BC110555

Consensus CDS

CCDS20053.1

UniProtKB/Swiss-Prot

P69744, Q2TB50

UniProtKB/TrEMBL

A0A0A6YW69

Related

ENSMUSP00000031901.6, ENSMUST00000031901.11

Conserved Domains (2) summary

TIGR00870
Location:5 → 701

trp; transient-receptor-potential calcium channel protein

sd00045
Location:111 → 154

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

41628595..41658158 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321464.2 → XP_017176953.1 transient receptor potential cation channel subfamily V member 5 isoform X2

UniProtKB/TrEMBL

A0A0A6YW69

Conserved Domains (2) summary

TIGR00870
Location:5 → 655

trp; transient-receptor-potential calcium channel protein

sd00045
Location:73 → 101

ANK; ANK repeat [structural motif]
XM_017321463.2 → XP_017176952.1 transient receptor potential cation channel subfamily V member 5 isoform X1

UniProtKB/Swiss-Prot

P69744, Q2TB50

UniProtKB/TrEMBL

A0A0A6YW69

Conserved Domains (2) summary

TIGR00870
Location:5 → 701

trp; transient-receptor-potential calcium channel protein

sd00045
Location:111 → 154

ANK; ANK repeat [structural motif]
XM_006505770.4 → XP_006505833.1 transient receptor potential cation channel subfamily V member 5 isoform X3

UniProtKB/TrEMBL

A0A0A6YW69

Conserved Domains (2) summary

TIGR00870
Location:15 → 650

trp; transient-receptor-potential calcium channel protein

sd00045
Location:60 → 103

ANK; ANK repeat [structural motif]
XM_006505771.2 → XP_006505834.1 transient receptor potential cation channel subfamily V member 5 isoform X4

UniProtKB/TrEMBL

A0A0A6YW69

Conserved Domains (2) summary

TIGR00870
Location:1 → 582

trp; transient-receptor-potential calcium channel protein

sd00045
Location:37 → 68

ANK; ANK repeat [structural motif]