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    Terc telomerase RNA component [ Mus musculus (house mouse) ]

    Gene ID: 21748, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tercprovided by MGI
    Official Full Name
    telomerase RNA componentprovided by MGI
    Primary source
    MGI:MGI:109558
    See related
    Ensembl:ENSMUSG00000118406 AllianceGenome:MGI:109558
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mTR; mTER
    Summary
    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human telomerase, murine telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]
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    Genomic context

    See Terc in Genome Data Viewer
    Location:
    3 F2.1; 3 41.82 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96321753..96322149, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96414437..96414833, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit, pseudogene 1 Neighboring gene nuclear encoded tRNA histidine 6 (anticodon GTG) Neighboring gene STARR-seq mESC enhancer starr_08427 Neighboring gene predicted gene, 24136 Neighboring gene nuclear encoded tRNA glycine 6 (anticodon CCC)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_001579.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF221922
      Related
      ENSMUST00000238714.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96321753..96322149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)