Fshr follicle stimulating hormone receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fshrprovided by MGI
Official Full Name: follicle stimulating hormone receptorprovided by MGI
Primary source: MGI:MGI:95583
See related: Ensembl:ENSMUSG00000032937 AllianceGenome:MGI:95583
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables follicle-stimulating hormone receptor activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; gonad development; and regulation of signal transduction. Located in cell surface. Is expressed in early conceptus and gonad. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward ovary adult (RPKM 9.2) See more
Orthologs: human all
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Genomic context

Location:: 17 58.76 cM; 17 E5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (89292380..89508103, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (88984952..89200675, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FSHR-mTOR-HIF1 signaling alleviates mouse follicles from AMPK-induced atresia.
Title: FSHR-mTOR-HIF1 signaling alleviates mouse follicles from AMPK-induced atresia.
The Luteinizing Hormone Receptor Knockout Mouse as a Tool to Probe the In Vivo Actions of Gonadotropic Hormones/Receptors in Females.
Title: The Luteinizing Hormone Receptor Knockout Mouse as a Tool to Probe the In Vivo Actions of Gonadotropic Hormones/Receptors in Females.
FSHR ablation induces depression-like behaviors.
Title: FSHR ablation induces depression-like behaviors.
FSH signaling is involved in affective disorders.
Title: FSH signaling is involved in affective disorders.
Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis.
Title: Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis.
Fshr is essential for normal angiogenesis of the fetal placental vasculature.
Title: Deletion of fetoplacental Fshr inhibits fetal vessel angiogenesis in the mouse placenta.
These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr expression.
Title: Interleukin 1-alpha deficiency increases the expression of Follicle-stimulating hormone receptors in granulosa cells.
Mouse chondrocytes and human articular cartilage express functional FSHR. Moreover, FSH can act on chondrocytes and cause genetic changes.
Title: Expression of FSHR in chondrocytes and the effect of FSH on chondrocytes.
Study demonstrates expression of follicle-stimulating hormone receptor (FSHR) and a direct action of follicle-stimulating hormone on testicular stem/germ cells possibly mediated via alternatively spliced growth factor type 1 receptor FSHR3 in mice.
Title: Testicular Stem Cells Express Follicle-Stimulating Hormone Receptors and Are Directly Modulated by FSH.
FSHR and LHR proteins are significantly upregulated in CCs surrounding oocytes arrested at the 2-cell stage, reflecting their developmental incompetence.
Title: FSH and LH receptors are differentially expressed in cumulus cells surrounding developmentally competent and incompetent mouse fully grown antral oocytes.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

General gene information

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Markers

FSHR (e-PCR)
- UniSTS:264013

G65759 (e-PCR)
- UniSTS:225898

Fshr (e-PCR), detects polymorphism
- UniSTS:526969

Fshr (e-PCR), detects polymorphism
- UniSTS:305549

Fshr (e-PCR), detects polymorphism
- UniSTS:305550

Lhcgr (e-PCR), detects polymorphism
- UniSTS:305551

Lhcgr (e-PCR), detects polymorphism
- UniSTS:305552

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables follicle-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables follicle-stimulating hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables follicle-stimulating hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Sertoli cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Sertoli cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to follicle-stimulating hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in follicle-stimulating hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within follicle-stimulating hormone signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in follicle-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovulation cycle process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within primary ovarian follicle growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of acetylcholine metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sperm DNA condensation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcytosis	IEA Inferred from Electronic Annotation more info
involved_in transcytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: follicle-stimulating hormone receptor

Names: follitropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013523.3 → NP_038551.3 follicle-stimulating hormone receptor precursor

See identical proteins and their annotated locations for NP_038551.3

Status: VALIDATED

Source sequence(s)

AC165082, BC137990, CT009630

Consensus CDS

CCDS29026.1

UniProtKB/Swiss-Prot

P35378, Q9D4C2, Q9QWV8

UniProtKB/TrEMBL

B2RQM3

Related

ENSMUSP00000040477.5, ENSMUST00000035701.6

Conserved Domains (5) summary

sd00033
Location:48 → 71

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:378 → 625

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam01462
Location:17 → 45

LRRNT; Leucine rich repeat N-terminal domain

pfam12369
Location:282 → 348

GnHR_trans; Gonadotropin hormone receptor transmembrane region

pfam13855
Location:72 → 132

LRR_8; Leucine rich repeat