Krt77 keratin 77 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt77provided by MGI
Official Full Name: keratin 77provided by MGI
Primary source: MGI:MGI:3588209
See related: Ensembl:ENSMUSG00000067594 AllianceGenome:MGI:3588209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K77; mK1b; CK-1B; K1emb; Krt239; 4732484G22Rik
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Is active in cornified envelope. Is expressed in epidermis; palmar pad; and skin. Orthologous to human KRT77 (keratin 77). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 6.1), limb E14.5 (RPKM 5.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.08 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101767166..101778141, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101858731..101869706, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Krt77 is the highest expressed gene among keratins in epidermis embryonic development.
Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.
sequence of novel type II keratin site-specifically deiminated in embryonic mouse epidermis.
Title: Prediction of a coding sequence for a novel type II keratin from N-terminal sequences of mouse epidermal proteins site-specifically deiminated in embryonic development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 1b

Names: cytokeratin-1B; embryonic type II keratin 1; keratin 1b; keratin complex 2, basic, gene 39; type II keratin Kb39; type-II intermediate filament protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003667.2 → NP_001003667.1 keratin, type II cytoskeletal 1b

See identical proteins and their annotated locations for NP_001003667.1

Status: VALIDATED

Source sequence(s)

AA880500, AC104862, AK132513, BK003993

Consensus CDS

CCDS27865.1

UniProtKB/Swiss-Prot

Q6IFZ6

UniProtKB/TrEMBL

Q08EK4, Q08EK5

Related

ENSMUSP00000085311.6, ENSMUST00000087996.7

Conserved Domains (2) summary

pfam00038
Location:166 → 479

Filament; Intermediate filament protein

pfam16208
Location:51 → 163

Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

101767166..101778141 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521140.1 → XP_006521203.1 keratin, type II cytoskeletal 1b isoform X1

UniProtKB/TrEMBL

Q08EK4

Conserved Domains (2) summary

pfam00038
Location:166 → 479

Filament; Intermediate filament protein

pfam16208
Location:51 → 163

Keratin_2_head; Keratin type II head
XM_017316690.1 → XP_017172179.1 keratin, type II cytoskeletal 1b isoform X2

Conserved Domains (1) summary

pfam00038
Location:1 → 234

Filament; Intermediate filament protein
XM_030248628.1 → XP_030104488.1 keratin, type II cytoskeletal 1b isoform X3

Conserved Domains (1) summary

pfam00038
Location:1 → 234

Filament; Intermediate filament protein