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    Gphb5 glycoprotein hormone beta 5 [ Mus musculus (house mouse) ]

    Gene ID: 217674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gphb5provided by MGI
    Official Full Name
    glycoprotein hormone beta 5provided by MGI
    Primary source
    MGI:MGI:2156540
    See related
    Ensembl:ENSMUSG00000048982 AllianceGenome:MGI:2156540
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OGH; Zlut1
    Summary
    Predicted to enable protein heterodimerization activity and thyrotropin-releasing hormone receptor binding activity. Acts upstream of or within regulation of thyroid hormone receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Orthologous to human GPHB5 (glycoprotein hormone subunit beta 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gphb5 in Genome Data Viewer
    Location:
    12 C3; 12 32.71 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (75458494..75463555, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (75411720..75416781, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32489 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 5 Neighboring gene STARR-seq mESC enhancer starr_32490 Neighboring gene ras homolog family member J Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76492550-76492789 Neighboring gene STARR-seq mESC enhancer starr_32491 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76550614-76550799 Neighboring gene STARR-seq mESC enhancer starr_32492 Neighboring gene predicted gene, 34613 Neighboring gene protein phosphatase 2, regulatory subunit B', epsilon Neighboring gene STARR-seq mESC enhancer starr_32494 Neighboring gene STARR-seq mESC enhancer starr_32495 Neighboring gene STARR-positive B cell enhancer ABC_E2388 Neighboring gene predicted gene, 34666

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness. van Zeijl CJ, et al. Am J Physiol Endocrinol Metab, 2014 Sep 15. PMID 25117405
    2. Acute inflammation increases pituitary and hypothalamic glycoprotein hormone subunit B5 mRNA expression in association with decreased thyrotrophin receptor mRNA expression in mice. van Zeijl CJ, et al. J Neuroendocrinol, 2011 Apr. PMID 21314737
    3. Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice. van Zeijl CJ, et al. Mol Cell Endocrinol, 2010 Jun 10. PMID 20223276
    4. Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development. Bassett JH, et al. Endocrinology, 2015 Sep. PMID 26018249, Free PMC Article
    5. A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor. Okada SL, et al. Mol Endocrinol, 2006 Feb. PMID 16210345

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expressed in newborn skulls and long bones but declined rapidly thereafter
      Title: Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.
    2. lacking GPB5 during acute illness does not affect the LPS-induced decrease of serum thyroid hormones
      Title: Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness.
    3. Results demonstrate in vivo regulation of central GPB5 transcription during acute illness.
      Title: Acute inflammation increases pituitary and hypothalamic glycoprotein hormone subunit B5 mRNA expression in association with decreased thyrotrophin receptor mRNA expression in mice.
    4. when GPB5-TG mice are challenged with a high-fat diet, they gain significantly less weight and body fat than their WT littermates
      Title: Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thyrotropin-releasing hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thyrotropin-releasing hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of thyroid hormone receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of thyroid hormone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycoprotein hormone beta-5
    Names
    glycoprotein hormone beta subunit
    thyrostimulin subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175644.3 → NP_783575.2  glycoprotein hormone beta-5 precursor

      See identical proteins and their annotated locations for NP_783575.2

      Status: VALIDATED

      Source sequence(s)
      AC124414
      Consensus CDS
      CCDS25982.1
      UniProtKB/Swiss-Prot
      Q812B2, Q8BJV2
      UniProtKB/TrEMBL
      B2RTN6, Q2NL39
      Related
      ENSMUSP00000061488.3, ENSMUST00000051079.4
      Conserved Domains (1) summary
      cd00069
      Location:36 → 129
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      75458494..75463555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315024.1 → XP_017170513.1  glycoprotein hormone beta-5 isoform X1

      UniProtKB/Swiss-Prot
      Q812B2, Q8BJV2
      UniProtKB/TrEMBL
      B2RTN6, Q2NL39
      Conserved Domains (1) summary
      cd00069
      Location:36 → 129
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q812B2.1 GenPept UniProtKB/Swiss-Prot:Q812B2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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