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    Prcp prolylcarboxypeptidase (angiotensinase C) [ Mus musculus (house mouse) ]

    Gene ID: 72461, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prcpprovided by MGI
    Official Full Name
    prolylcarboxypeptidase (angiotensinase C)provided by MGI
    Primary source
    MGI:MGI:1919711
    See related
    Ensembl:ENSMUSG00000061119 AllianceGenome:MGI:1919711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCP; HUMPCP; 2510048K03Rik; 2610104A14Rik
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Acts upstream of or within several processes, including angiogenesis involved in wound healing; plasma kallikrein-kinin cascade; and regulation of thyroid hormone receptor signaling pathway. Located in basal part of cell and lysosome. Is expressed in several structures, including axial musculature; brain meninges; craniocervical region bone; foregut; and liver lobe. Orthologous to human PRCP (prolylcarboxypeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 12.8), placenta adult (RPKM 12.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prcp in Genome Data Viewer
    Location:
    7 E1; 7 51.64 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (92524461..92583789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (92875253..92934581)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19530 Neighboring gene RAB30, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E8184 Neighboring gene STARR-seq mESC enhancer starr_19531 Neighboring gene STARR-positive B cell enhancer ABC_E9697 Neighboring gene STARR-seq mESC enhancer starr_19532 Neighboring gene DNA damage-induced apoptosis suppressor Neighboring gene predicted gene, 40448 Neighboring gene predicted gene, 31663 Neighboring gene STARR-seq mESC enhancer starr_19533 Neighboring gene VISTA enhancer mm1534 Neighboring gene family with sequence similarity 181, member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallocarboxypeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis involved in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within angiogenesis involved in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiotensin maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within plasma kallikrein-kinin cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood vessel endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of thyroid hormone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysosomal Pro-X carboxypeptidase
    Names
    proline carboxypeptidase
    NP_082519.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028243.3NP_082519.1  lysosomal Pro-X carboxypeptidase precursor

      See identical proteins and their annotated locations for NP_082519.1

      Status: VALIDATED

      Source sequence(s)
      AC158138, AK051677
      Consensus CDS
      CCDS21452.1
      UniProtKB/Swiss-Prot
      Q3TLW3, Q3V302, Q7TMR0, Q8BKK3, Q8R0T8, Q9D049
      UniProtKB/TrEMBL
      A0A140LHY2
      Related
      ENSMUSP00000075429.7, ENSMUST00000076052.8
      Conserved Domains (2) summary
      COG0596
      Location:102204
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:53472
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      92524461..92583789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)