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    Mlycd malonyl-CoA decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 56690, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mlycdprovided by MGI
    Official Full Name
    malonyl-CoA decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:1928485
    See related
    Ensembl:ENSMUSG00000074064 AllianceGenome:MGI:1928485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcd
    Summary
    Enables malonyl-CoA decarboxylase activity. Involved in malonyl-CoA catabolic process and positive regulation of fatty acid oxidation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; nervous system; nose; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in cardiomyopathy. Orthologous to human MLYCD (malonyl-CoA decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 29.4), liver adult (RPKM 25.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mlycd in Genome Data Viewer
    Location:
    8 E1; 8 67.64 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120121591..120148577)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119394852..119421838)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10525 Neighboring gene heat shock factor binding protein 1 Neighboring gene predicted gene 45723 Neighboring gene STARR-positive B cell enhancer ABC_E3809 Neighboring gene predicted gene, 32006 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:121947490-121947599 Neighboring gene STARR-positive B cell enhancer ABC_E2879 Neighboring gene STARR-positive B cell enhancer ABC_E10526 Neighboring gene oxidative stress induced growth inhibitor 1 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene predicted gene, 53462

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables malonyl-CoA decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables malonyl-CoA decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables malonyl-CoA decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables malonyl-CoA decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acetyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acetyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetyl-CoA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in malonyl-CoA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in malonyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in malonyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in malonyl-CoA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    malonyl-CoA decarboxylase, mitochondrial
    NP_001351257.1
    NP_064350.2
    XP_006531281.1
    XP_006531285.1
    XP_006531288.1
    XP_006531289.1
    XP_011246759.1
    XP_017168411.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364328.1NP_001351257.1  malonyl-CoA decarboxylase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166781
      Conserved Domains (1) summary
      pfam05292
      Location:94365
      MCD; Malonyl-CoA decarboxylase (MCD)
    2. NM_019966.3NP_064350.2  malonyl-CoA decarboxylase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_064350.2

      Status: VALIDATED

      Source sequence(s)
      AC166781
      Consensus CDS
      CCDS22703.1
      UniProtKB/Swiss-Prot
      Q7TNL6, Q99J39
      Related
      ENSMUSP00000095970.5, ENSMUST00000098367.5
      Conserved Domains (1) summary
      pfam05292
      Location:94455
      MCD; Malonyl-CoA decarboxylase (MCD)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120121591..120148577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248457.4XP_011246759.1  malonyl-CoA decarboxylase, mitochondrial isoform X2

      Conserved Domains (2) summary
      pfam05292
      Location:192315
      MCD; Malonyl-CoA decarboxylase C-terminal domain
      pfam17408
      Location:94189
      MCD_N; Malonyl-CoA decarboxylase N-terminal domain
    2. XM_017312922.3XP_017168411.1  malonyl-CoA decarboxylase, mitochondrial isoform X4

      Conserved Domains (2) summary
      pfam05292
      Location:192315
      MCD; Malonyl-CoA decarboxylase C-terminal domain
      pfam17408
      Location:94189
      MCD_N; Malonyl-CoA decarboxylase N-terminal domain
    3. XM_006531222.5XP_006531285.1  malonyl-CoA decarboxylase, mitochondrial isoform X3

      Conserved Domains (2) summary
      pfam05292
      Location:192315
      MCD; Malonyl-CoA decarboxylase C-terminal domain
      pfam17408
      Location:94189
      MCD_N; Malonyl-CoA decarboxylase N-terminal domain
    4. XM_006531225.5XP_006531288.1  malonyl-CoA decarboxylase, mitochondrial isoform X5

      Conserved Domains (2) summary
      pfam05292
      Location:192315
      MCD; Malonyl-CoA decarboxylase C-terminal domain
      pfam17408
      Location:94189
      MCD_N; Malonyl-CoA decarboxylase N-terminal domain
    5. XM_006531226.5XP_006531289.1  malonyl-CoA decarboxylase, mitochondrial isoform X6

      Conserved Domains (2) summary
      pfam05292
      Location:192316
      MCD; Malonyl-CoA decarboxylase C-terminal domain
      pfam17408
      Location:94189
      MCD_N; Malonyl-CoA decarboxylase N-terminal domain
    6. XM_006531218.5XP_006531281.1  malonyl-CoA decarboxylase, mitochondrial isoform X1

      Conserved Domains (2) summary
      pfam05292
      Location:174437
      MCD; Malonyl-CoA decarboxylase C-terminal domain
      pfam17408
      Location:105171
      MCD_N; Malonyl-CoA decarboxylase N-terminal domain