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    Myom3 myomesin family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 242702, updated on 27-Nov-2024

    Summary

    Official Symbol
    Myom3provided by MGI
    Official Full Name
    myomesin family, member 3provided by MGI
    Primary source
    MGI:MGI:2685280
    See related
    Ensembl:ENSMUSG00000037139 AllianceGenome:MGI:2685280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm434; 8430427K15Rik
    Summary
    Enables protein homodimerization activity. Predicted to be involved in sarcomere organization. Located in M band. Is expressed in diaphragm; leg; skeletal musculature; and somite. Orthologous to human MYOM3 (myomesin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 2.0), placenta adult (RPKM 0.8) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Myom3 in Genome Data Viewer
    Location:
    4 D3; 4 68.0 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135486688..135542882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135758800..135815571)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene interleukin 22 receptor, alpha 1 Neighboring gene S-phase kinase-associated protein 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_11736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135411492-135411675 Neighboring gene STARR-positive B cell enhancer ABC_E7999 Neighboring gene serine and arginine-rich splicing factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E4683 Neighboring gene proline-rich nuclear receptor coactivator 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in M band IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085509.2NP_001078978.1  myomesin-3

      See identical proteins and their annotated locations for NP_001078978.1

      Status: VALIDATED

      Source sequence(s)
      AL662911
      Consensus CDS
      CCDS38921.1
      UniProtKB/Swiss-Prot
      A2ABU4
      Related
      ENSMUSP00000101480.2, ENSMUST00000105854.2
      Conserved Domains (5) summary
      cd00096
      Location:171244
      Ig; Immunoglobulin domain
      smart00410
      Location:11371207
      IG_like; Immunoglobulin like
      cd00063
      Location:804893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:13431426
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:13361426
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135486688..135542882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320223.3XP_017175712.1  myomesin-3 isoform X1

      Conserved Domains (3) summary
      cd00063
      Location:804893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:154247
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:272363
      Ig; Immunoglobulin domain
    2. XM_017320224.2XP_017175713.1  myomesin-3 isoform X2

      Conserved Domains (3) summary
      cd00063
      Location:221310
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:555619
      Ig; Immunoglobulin domain
      cl11960
      Location:753843
      Ig; Immunoglobulin domain

    RNA

    1. XR_003954947.2 RNA Sequence