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    Tmem25 transmembrane protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 71687, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem25provided by MGI
    Official Full Name
    transmembrane protein 25provided by MGI
    Primary source
    MGI:MGI:1918937
    See related
    Ensembl:ENSMUSG00000002032 AllianceGenome:MGI:1918937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610039J01Rik
    Summary
    Involved in negative regulation of excitatory postsynaptic potential and regulation of protein stability. Located in late endosome and lysosome. Is expressed in basioccipital bone; orbito-sphenoid; and temporal bone petrous part. Orthologous to human TMEM25 (transmembrane protein 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 44.3), liver adult (RPKM 27.1) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmem25 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44705069..44710821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44793772..44799524, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene archain 1 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene intraflagellar transport 46 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene lysine (K)-specific methyltransferase 2A Neighboring gene predicted gene, 39326 Neighboring gene STARR-positive B cell enhancer ABC_E6728 Neighboring gene STARR-seq mESC enhancer starr_23986 Neighboring gene predicted gene, 30883

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357383.1NP_001344312.1  transmembrane protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC142113
      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (1) summary
      cl11960
      Location:51142
      Ig; Immunoglobulin domain
    2. NM_001357384.1NP_001344313.1  transmembrane protein 25 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC142113
      Consensus CDS
      CCDS23120.1
      UniProtKB/Swiss-Prot
      Q3TMP3, Q6PAK7, Q9DCF1
      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (2) summary
      cd00096
      Location:3034
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27118
      Ig; Immunoglobulin domain
    3. NM_001357385.1NP_001344314.1  transmembrane protein 25 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC142113
      Consensus CDS
      CCDS23120.1
      UniProtKB/Swiss-Prot
      Q3TMP3, Q6PAK7, Q9DCF1
      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (2) summary
      cd00096
      Location:3034
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27118
      Ig; Immunoglobulin domain
    4. NM_001357386.1NP_001344315.1  transmembrane protein 25 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC142113, AK090375, AW457301
      Consensus CDS
      CCDS90554.1
      UniProtKB/TrEMBL
      A0A1N9MYB8
      Related
      ENSMUSP00000110353.3, ENSMUST00000114705.9
      Conserved Domains (2) summary
      cd00096
      Location:3034
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27118
      Ig; Immunoglobulin domain
    5. NM_027865.3NP_082141.1  transmembrane protein 25 isoform b precursor

      See identical proteins and their annotated locations for NP_082141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AK165199, AW457301
      Consensus CDS
      CCDS23120.1
      UniProtKB/Swiss-Prot
      Q3TMP3, Q6PAK7, Q9DCF1
      UniProtKB/TrEMBL
      Q3U4J4
      Related
      ENSMUSP00000002100.8, ENSMUST00000002100.8
      Conserved Domains (2) summary
      cd00096
      Location:3034
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27118
      Ig; Immunoglobulin domain

    RNA

    1. NR_151678.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC142113
    2. NR_151679.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC142113
      Related
      ENSMUST00000132020.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44705069..44710821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244613.1XP_030100473.1  transmembrane protein 25 isoform X4

      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (1) summary
      cl11960
      Location:52143
      Ig; Immunoglobulin domain
    2. XM_030244612.1XP_030100472.1  transmembrane protein 25 isoform X3

      Conserved Domains (1) summary
      cl11960
      Location:127218
      Ig; Immunoglobulin domain
    3. XM_030244611.1XP_030100471.1  transmembrane protein 25 isoform X2

      Conserved Domains (1) summary
      cl11960
      Location:128219
      Ig; Immunoglobulin domain
    4. XM_030244609.1XP_030100469.1  transmembrane protein 25 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:128219
      Ig; Immunoglobulin domain
    5. XM_030244614.2XP_030100474.1  transmembrane protein 25 isoform X7

      Conserved Domains (1) summary
      cl11960
      Location:51142
      Ig; Immunoglobulin domain
    6. XM_036155294.1XP_036011187.1  transmembrane protein 25 isoform X9

    7. XM_036155292.1XP_036011185.1  transmembrane protein 25 isoform X6

      Conserved Domains (2) summary
      cd00096
      Location:5559
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:52143
      Ig; Immunoglobulin domain
    8. XM_011242601.3XP_011240903.1  transmembrane protein 25 isoform X9

      See identical proteins and their annotated locations for XP_011240903.1

    9. XM_030244615.2XP_030100475.1  transmembrane protein 25 isoform X9

    10. XM_036155293.1XP_036011186.1  transmembrane protein 25 isoform X8

      UniProtKB/TrEMBL
      A0A1N9MYB8
      Conserved Domains (2) summary
      cd00096
      Location:3034
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27118
      Ig; Immunoglobulin domain
    11. XM_006510610.4XP_006510673.1  transmembrane protein 25 isoform X5

      See identical proteins and their annotated locations for XP_006510673.1

      UniProtKB/Swiss-Prot
      Q3TMP3, Q6PAK7, Q9DCF1
      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (2) summary
      cd00096
      Location:3034
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27118
      Ig; Immunoglobulin domain
    12. XM_036155295.1XP_036011188.1  transmembrane protein 25 isoform X9

    13. XM_011242602.1XP_011240904.1  transmembrane protein 25 isoform X9

      See identical proteins and their annotated locations for XP_011240904.1

    14. XM_030244616.1XP_030100476.1  transmembrane protein 25 isoform X9

    15. XM_011242603.2XP_011240905.1  transmembrane protein 25 isoform X9

      See identical proteins and their annotated locations for XP_011240905.1