U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tpt1 tumor protein, translationally-controlled 1 [ Mus musculus (house mouse) ]

    Gene ID: 22070, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tpt1provided by MGI
    Official Full Name
    tumor protein, translationally-controlled 1provided by MGI
    Primary source
    MGI:MGI:104890
    See related
    Ensembl:ENSMUSG00000060126 AllianceGenome:MGI:104890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trt; p21; p23; TCTP
    Summary
    Enables DNA-binding transcription factor binding activity. Involved in negative regulation of ectoderm development and stem cell population maintenance. Located in nucleoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; sciatic nerve; and testis. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 1476.1), bladder adult (RPKM 983.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tpt1 in Genome Data Viewer
    Location:
    14 D3; 14 40.29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76082771..76085743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75845256..75848303)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37147 Neighboring gene predicted gene, 36271 Neighboring gene STARR-positive B cell enhancer ABC_E8900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:76234679-76234835 Neighboring gene STARR-positive B cell enhancer ABC_E9410 Neighboring gene predicted gene 4285 Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene STARR-seq mESC enhancer starr_37150 Neighboring gene STARR-positive B cell enhancer ABC_E10835 Neighboring gene predicted gene, 52138 Neighboring gene STARR-seq mESC enhancer starr_37153 Neighboring gene general transcription factor IIF, polypeptide 2 Neighboring gene armadillo repeat containing 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    translationally-controlled tumor protein
    Names
    21 kDa polypeptide under translational control
    fortilin
    translationally regulated transcript (21 kDa)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424592.1NP_001411521.1  translationally-controlled tumor protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140244
    2. NM_009429.4NP_033455.1  translationally-controlled tumor protein isoform 1

      See identical proteins and their annotated locations for NP_033455.1

      Status: VALIDATED

      Source sequence(s)
      AC140244
      Consensus CDS
      CCDS36980.1
      UniProtKB/Swiss-Prot
      P63028, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9
      UniProtKB/TrEMBL
      D3YU75
      Related
      ENSMUSP00000106519.3, ENSMUST00000110894.9
      Conserved Domains (1) summary
      pfam00838
      Location:1167
      TCTP; Translationally controlled tumor protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      76082771..76085743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)