UBXN2B UBX domain protein 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: UBXN2Bprovided by HGNC
Official Full Name: UBX domain protein 2Bprovided by HGNC
Primary source: HGNC:HGNC:27035
See related: Ensembl:ENSG00000215114 MIM:610686; AllianceGenome:HGNC:27035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p37
Summary: Predicted to enable ubiquitin binding activity. Involved in establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and spindle pole centrosome. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in brain (RPKM 9.6), thyroid (RPKM 8.2) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8q12.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (58411361..58451501)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (58832480..58872635)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (59323920..59364060)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor.
Title: In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor.
human p37/p47 and their C. elegans orthologue UBXN-2 regulate centrosome function in prophase by limiting the recruitment of Aurora A
Title: The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
these results demonstrate that p37 phosphorylation on Serine-56 and Threonine-59 is important for Golgi disassembly at mitosis.
Title: Phosphorylation of p37 is important for Golgi disassembly at mitosis.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH98878 (e-PCR)
- UniSTS:91933

RH81080 (e-PCR)
- UniSTS:88868

RH92458 (e-PCR)
- UniSTS:85079

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein localization to centrosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear membrane reassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitotic centrosome separation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole centrosome	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: UBX domain-containing protein 2B

Names: NSFL1 cofactor p37; p97 cofactor p37

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077619.2 → NP_001071087.1 UBX domain-containing protein 2B isoform 1

See identical proteins and their annotated locations for NP_001071087.1

Status: VALIDATED

Source sequence(s)

AK126300, BC113645, U79282

Consensus CDS

CCDS43741.1

UniProtKB/Swiss-Prot

B3KWZ3, Q14CS0

Related

ENSP00000382507.2, ENST00000399598.7

Conserved Domains (2) summary

cd01770
Location:253 → 331

p47_UBX; p47-like ubiquitin domain

smart00553
Location:140 → 232

SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
NM_001330535.2 → NP_001317464.1 UBX domain-containing protein 2B isoform 2

Status: VALIDATED

Source sequence(s)

BE502216, DA185219, DA242203

Consensus CDS

CCDS83297.1

UniProtKB/TrEMBL

E5RJ36

Related

ENSP00000428314.1, ENST00000523409.5

Conserved Domains (1) summary

cl02662
Location:146 → 178

SEP; SEP domain
NM_001363181.1 → NP_001350110.1 UBX domain-containing protein 2B isoform 3

Status: VALIDATED

Source sequence(s)

AK126300, BC113645, U79282

Conserved Domains (2) summary

cd01770
Location:207 → 285

p47_UBX; p47-like ubiquitin domain

cl02662
Location:146 → 182

SEP; SEP domain