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    OSBPL3 oxysterol binding protein like 3 [ Homo sapiens (human) ]

    Gene ID: 26031, updated on 10-Dec-2024

    Summary

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    Official Symbol
    OSBPL3provided by HGNC
    Official Full Name
    oxysterol binding protein like 3provided by HGNC
    Primary source
    HGNC:HGNC:16370
    See related
    Ensembl:ENSG00000070882 MIM:606732; AllianceGenome:HGNC:16370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ORP3; ORP-3; OSBP3
    Summary
    This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See OSBPL3 in Genome Data Viewer
    Location:
    7p15.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (24796537..24981845, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (24934545..25120219, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (24836156..25019797, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25748 Neighboring gene SUMO2 pseudogene 14 Neighboring gene protein associated with LIN7 2, MAGUK p55 family member Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:24725223-24725819 Neighboring gene Sharpr-MPRA regulatory region 3197 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:24744538-24744707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:24757299-24757886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25751 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24764003-24764686 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24765371-24766054 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24766055-24766736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25753 Neighboring gene Sharpr-MPRA regulatory region 13058 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18020 Neighboring gene gasdermin E Neighboring gene Sharpr-MPRA regulatory region 12520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25756 Neighboring gene MPRA-validated peak6442 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24834867-24835372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24834361-24834866 Neighboring gene NANOG hESC enhancer GRCh37_chr7:24841903-24842404 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:24865671-24866870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25760 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:24990225-24990724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:25010975-25011630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:25068437-25068938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:25098668-25099168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25767 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:25163804-25164348 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:25164349-25164892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25768 Neighboring gene uncharacterized LOC124901603 Neighboring gene uncharacterized LOC124901602 Neighboring gene sperm microtubule inner protein 4 Neighboring gene cytochrome c, somatic

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Oxysterol-binding proteins: functions in cell regulation beyond lipid metabolism. Weber-Boyvat M, et al. Biochem Pharmacol, 2013 Jul 1. PMID 23428468
    2. Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism. Olkkonen VM, et al. Prog Lipid Res, 2013 Oct. PMID 23830809
    3. Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis. Wang C, et al. BMC Gastroenterol, 2023 Aug 7. PMID 37550605, Free PMC Article
    4. The R-Ras interaction partner ORP3 regulates cell adhesion. Lehto M, et al. J Cell Sci, 2008 Mar 1. PMID 18270267
    5. Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants. Lehto M, et al. Exp Cell Res, 2005 Nov 1. PMID 16143324

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
      Title: Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
    2. Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis.
      Title: Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis.
    3. Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor gamma in fatty liver disease.
      Title: Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease.
    4. The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis.
      Title: The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis.
    5. Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer.
      Title: Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer.
    6. Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
      Title: Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
    7. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
      Title: Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
    8. Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer.
      Title: Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer.
    9. The crystal structure of ORP3 reveals the conservative PI4P binding pattern.
      Title: The crystal structure of ORP3 reveals the conservative PI4P binding pattern.
    10. Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.
      Title: Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of oxysterol binding protein-like 3 (OSBPL3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with oxysterol binding protein-like 3 (OSBPL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with oxysterol binding protein-like 3 (OSBPL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0704, MGC21526, DKFZp667P1518

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sterol transfer activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in sterol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 3
    Names
    OSBP-related protein 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015550.4 → NP_056365.1  oxysterol-binding protein-related protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Isoform a contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1a.
      Source sequence(s)
      AB014604, AC003093, AY008372, DR003143
      Consensus CDS
      CCDS5390.1
      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6
      Related
      ENSP00000315410.2, ENST00000313367.7
      Conserved Domains (2) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:527 → 871
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_145320.2 → NP_663160.1  oxysterol-binding protein-related protein 3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a. Isoform b contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1b.
      Source sequence(s)
      AB014604, AC003093, AF323727, AF491782, AW241639, AY008372
      Consensus CDS
      CCDS5391.1
      UniProtKB/Swiss-Prot
      Q9H4L5
      Related
      ENSP00000379708.1, ENST00000396431.5
      Conserved Domains (3) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:52 → 142
      PH; PH domain
      pfam01237
      Location:496 → 830
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_145321.2 → NP_663161.1  oxysterol-binding protein-related protein 3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1, resulting in a shorter isoform (c) compared to isoform a. Isoform c contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1c.
      Source sequence(s)
      AB014604, AC003093, AF323727, AF491783, AW241639, AY008372
      Consensus CDS
      CCDS5392.1
      UniProtKB/Swiss-Prot
      Q9H4L5
      Related
      ENSP00000379706.1, ENST00000396429.5
      Conserved Domains (3) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:52 → 142
      PH; PH domain
      pfam01237
      Location:491 → 825
      Oxysterol_BP; Oxysterol-binding protein

    4. NM_145322.2 → NP_663162.1  oxysterol-binding protein-related protein 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1, resulting in a shorter isoform (d) compared to isoform a. Isoform d contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1d.
      Source sequence(s)
      AB014604, AC003093, AF323727, AF491784, AW241639, AY008372
      Consensus CDS
      CCDS47564.1
      UniProtKB/Swiss-Prot
      Q9H4L5
      Related
      ENSP00000386953.1, ENST00000409069.5
      Conserved Domains (3) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:52 → 142
      PH; PH domain
      pfam01237
      Location:460 → 794
      Oxysterol_BP; Oxysterol-binding protein

    RNA

    1. NR_104111.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB014604, AC003093, AF323727, AF491785, AW241639, AY008372

    2. NR_104112.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in an internal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB014604, AC003093, AF323727, AF491786, AW241639, AY008372

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      24796537..24981845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420146.1 → XP_047276102.1  oxysterol-binding protein-related protein 3 isoform X5

    2. XM_047420134.1 → XP_047276090.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    3. XM_047420131.1 → XP_047276087.1  oxysterol-binding protein-related protein 3 isoform X1

    4. XM_047420148.1 → XP_047276104.1  oxysterol-binding protein-related protein 3 isoform X6

    5. XM_047420145.1 → XP_047276101.1  oxysterol-binding protein-related protein 3 isoform X5

    6. XM_047420137.1 → XP_047276093.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    7. XM_047420135.1 → XP_047276091.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    8. XM_006715683.4 → XP_006715746.1  oxysterol-binding protein-related protein 3 isoform X7

      UniProtKB/Swiss-Prot
      Q9H4L5
      Conserved Domains (3) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:52 → 142
      PH; PH domain
      pfam01237
      Location:460 → 794
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_006715681.4 → XP_006715744.1  oxysterol-binding protein-related protein 3 isoform X5

      UniProtKB/Swiss-Prot
      Q9H4L5
      Conserved Domains (3) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:52 → 142
      PH; PH domain
      pfam01237
      Location:496 → 830
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_047420139.1 → XP_047276095.1  oxysterol-binding protein-related protein 3 isoform X3

    11. XM_006715682.4 → XP_006715745.1  oxysterol-binding protein-related protein 3 isoform X6

      UniProtKB/Swiss-Prot
      Q9H4L5
      Conserved Domains (3) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:52 → 142
      PH; PH domain
      pfam01237
      Location:491 → 825
      Oxysterol_BP; Oxysterol-binding protein

    12. XM_047420142.1 → XP_047276098.1  oxysterol-binding protein-related protein 3 isoform X4

    13. XM_047420129.1 → XP_047276085.1  oxysterol-binding protein-related protein 3 isoform X1

    14. XM_047420136.1 → XP_047276092.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    15. XM_047420149.1 → XP_047276105.1  oxysterol-binding protein-related protein 3 isoform X6

    16. XM_047420138.1 → XP_047276094.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    17. XM_047420143.1 → XP_047276099.1  oxysterol-binding protein-related protein 3 isoform X5

    18. XM_047420140.1 → XP_047276096.1  oxysterol-binding protein-related protein 3 isoform X3

    19. XM_047420150.1 → XP_047276106.1  oxysterol-binding protein-related protein 3 isoform X6

    20. XM_005249698.4 → XP_005249755.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6
      Conserved Domains (2) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:527 → 871
      Oxysterol_BP; Oxysterol-binding protein

    21. XM_047420132.1 → XP_047276088.1  oxysterol-binding protein-related protein 3 isoform X1

    22. XM_047420151.1 → XP_047276107.1  oxysterol-binding protein-related protein 3 isoform X7

    23. XM_047420144.1 → XP_047276100.1  oxysterol-binding protein-related protein 3 isoform X5

    24. XM_047420141.1 → XP_047276097.1  oxysterol-binding protein-related protein 3 isoform X3

    25. XM_047420147.1 → XP_047276103.1  oxysterol-binding protein-related protein 3 isoform X6

    26. XM_011515258.3 → XP_011513560.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6
      Conserved Domains (2) summary
      cd13287
      Location:31 → 153
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:527 → 871
      Oxysterol_BP; Oxysterol-binding protein

    27. XM_047420130.1 → XP_047276086.1  oxysterol-binding protein-related protein 3 isoform X1

    28. XM_047420133.1 → XP_047276089.1  oxysterol-binding protein-related protein 3 isoform X1

    29. XM_047420153.1 → XP_047276109.1  oxysterol-binding protein-related protein 3 isoform X9

    30. XM_047420152.1 → XP_047276108.1  oxysterol-binding protein-related protein 3 isoform X8

    RNA

    1. XR_007060001.1 RNA Sequence

    2. XR_007060007.1 RNA Sequence

    3. XR_007060005.1 RNA Sequence

    4. XR_007060006.1 RNA Sequence

    5. XR_007060004.1 RNA Sequence

    6. XR_007060002.1 RNA Sequence

    7. XR_007060003.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      24934545..25120219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357787.1 → XP_054213762.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    2. XM_054357801.1 → XP_054213776.1  oxysterol-binding protein-related protein 3 isoform X5

    3. XM_054357802.1 → XP_054213777.1  oxysterol-binding protein-related protein 3 isoform X5

    4. XM_054357805.1 → XP_054213780.1  oxysterol-binding protein-related protein 3 isoform X6

    5. XM_054357792.1 → XP_054213767.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    6. XM_054357784.1 → XP_054213759.1  oxysterol-binding protein-related protein 3 isoform X1

    7. XM_054357790.1 → XP_054213765.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    8. XM_054357808.1 → XP_054213783.1  oxysterol-binding protein-related protein 3 isoform X7

    9. XM_054357798.1 → XP_054213773.1  oxysterol-binding protein-related protein 3 isoform X5

    10. XM_054357794.1 → XP_054213769.1  oxysterol-binding protein-related protein 3 isoform X3

    11. XM_054357803.1 → XP_054213778.1  oxysterol-binding protein-related protein 3 isoform X6

    12. XM_054357797.1 → XP_054213772.1  oxysterol-binding protein-related protein 3 isoform X4

    13. XM_054357782.1 → XP_054213757.1  oxysterol-binding protein-related protein 3 isoform X1

    14. XM_054357791.1 → XP_054213766.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    15. XM_054357806.1 → XP_054213781.1  oxysterol-binding protein-related protein 3 isoform X6

    16. XM_054357793.1 → XP_054213768.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    17. XM_054357786.1 → XP_054213761.1  oxysterol-binding protein-related protein 3 isoform X1

    18. XM_054357796.1 → XP_054213771.1  oxysterol-binding protein-related protein 3 isoform X3

    19. XM_054357807.1 → XP_054213782.1  oxysterol-binding protein-related protein 3 isoform X6

    20. XM_054357799.1 → XP_054213774.1  oxysterol-binding protein-related protein 3 isoform X5

    21. XM_054357788.1 → XP_054213763.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    22. XM_054357785.1 → XP_054213760.1  oxysterol-binding protein-related protein 3 isoform X1

    23. XM_054357809.1 → XP_054213784.1  oxysterol-binding protein-related protein 3 isoform X7

    24. XM_054357800.1 → XP_054213775.1  oxysterol-binding protein-related protein 3 isoform X5

    25. XM_054357795.1 → XP_054213770.1  oxysterol-binding protein-related protein 3 isoform X3

    26. XM_054357804.1 → XP_054213779.1  oxysterol-binding protein-related protein 3 isoform X6

    27. XM_054357789.1 → XP_054213764.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

    28. XM_054357783.1 → XP_054213758.1  oxysterol-binding protein-related protein 3 isoform X1

    29. XM_054357811.1 → XP_054213786.1  oxysterol-binding protein-related protein 3 isoform X9

    30. XM_054357810.1 → XP_054213785.1  oxysterol-binding protein-related protein 3 isoform X8

    RNA

    1. XR_008487556.1 RNA Sequence

    2. XR_008487562.1 RNA Sequence

    3. XR_008487560.1 RNA Sequence

    4. XR_008487561.1 RNA Sequence

    5. XR_008487559.1 RNA Sequence

    6. XR_008487557.1 RNA Sequence

    7. XR_008487558.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145323.1: Suppressed sequence

      Description
      NM_145323.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.

    2. NM_145324.1: Suppressed sequence

      Description
      NM_145324.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H4L5.1 GenPept UniProtKB/Swiss-Prot:Q9H4L5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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