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    CTRL chymotrypsin like [ Homo sapiens (human) ]

    Gene ID: 1506, updated on 9-Dec-2024

    Summary

    Official Symbol
    CTRLprovided by HGNC
    Official Full Name
    chymotrypsin likeprovided by HGNC
    Primary source
    HGNC:HGNC:2524
    See related
    Ensembl:ENSG00000141086 MIM:118888; AllianceGenome:HGNC:2524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTRL1
    Summary
    This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016]
    Expression
    Restricted expression toward pancreas (RPKM 884.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CTRL in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67929574..67931862, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73725348..73727636, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67963477..67965765, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67907171-67907671 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918365-67918874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918875-67919382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7632 Neighboring gene neuritin 1 like Neighboring gene protein serine kinase H1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67944133-67944345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67949619-67950142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67953295-67953800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67960875-67961376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67962749-67963459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67964222-67964739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67964740-67965256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67973687-67974296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67976255-67977154 Neighboring gene proteasome 20S subunit beta 10 Neighboring gene solute carrier family 12 member 4 Neighboring gene lecithin-cholesterol acyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: PSMB10

    Clone Names

    • MGC70821

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    chymotrypsin-like protease CTRL-1
    NP_001898.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051639.1 RefSeqGene

      Range
      5014..7302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001907.3NP_001898.1  chymotrypsin-like protease CTRL-1 precursor

      See identical proteins and their annotated locations for NP_001898.1

      Status: REVIEWED

      Source sequence(s)
      X71877
      Consensus CDS
      CCDS10852.1
      UniProtKB/Swiss-Prot
      P40313
      UniProtKB/TrEMBL
      Q53FV9
      Related
      ENSP00000458537.2, ENST00000574481.6
      Conserved Domains (1) summary
      cd00190
      Location:34260
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67929574..67931862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73725348..73727636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)