Camsap2 calmodulin regulated spectrin-associated protein family, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camsap2provided by RGD
Official Full Name: calmodulin regulated spectrin-associated protein family, member 2provided by RGD
Primary source: RGD:1310950
See related: EnsemblRapid:ENSRNOG00000008741 AllianceGenome:RGD:1310950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Camsap1l1; RGD1310950
Summary: Predicted to enable microtubule minus-end binding activity. Involved in axon development and regulation of dendrite development. Predicted to be located in Golgi apparatus; cytosol; and microtubule cytoskeleton. Predicted to colocalize with microtubule minus-end. Orthologous to human CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 292.1), Lung (RPKM 162.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (50274950..50354298, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (47723251..47802606, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (53145712..53225349, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In summary, CAMSAP2 is a regulator of microtubule and actin dynamics in Sertoli cells to support blood-testis barrier dynamics and spermatogenesis.
Title: CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization.

Submit: New GeneRIF Correction

General gene information

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Markers

BF389061 (e-PCR)
- UniSTS:261657

D13Got37 (e-PCR)
- UniSTS:111715

RH134461 (e-PCR)
- UniSTS:217741

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule minus-end binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of organelle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule end	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule minus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule minus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule minus-end	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calmodulin-regulated spectrin-associated protein 2

Names: calmodulin regulated spectrin-associated protein 1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134503.2 → NP_001127975.1 calmodulin-regulated spectrin-associated protein 2 isoform 1

See identical proteins and their annotated locations for NP_001127975.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

A0A0G2K7K9, D4AEC2

UniProtKB/TrEMBL

A0A8I6A5G7

Conserved Domains (4) summary

pfam08683
Location:1331 → 1449

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:237 → 315

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:737 → 787

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

cl26464
Location:915 → 1028

Atrophin-1; Atrophin-1 family
NM_001415803.1 → NP_001402732.1 calmodulin-regulated spectrin-associated protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

Related

ENSRNOP00000088623.1, ENSRNOT00000098757.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

50274950..50354298 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272200.1 → XP_063128270.1 calmodulin-regulated spectrin-associated protein 2 isoform X5

Related

ENSRNOP00000106071.1, ENSRNOT00000168494.1
XM_039090610.2 → XP_038946538.1 calmodulin-regulated spectrin-associated protein 2 isoform X2

UniProtKB/TrEMBL

A0A5H1ZRV8, A0A8I6A5G7

Related

ENSRNOP00000074249.2, ENSRNOT00000091015.3

Conserved Domains (4) summary

PHA03247
Location:904 → 1017

PHA03247; large tegument protein UL36; Provisional

pfam11971
Location:226 → 304

CAMSAP_CH; CAMSAP CH domain

pfam08683
Location:1329 → 1447

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam17095
Location:726 → 776

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_063272199.1 → XP_063128269.1 calmodulin-regulated spectrin-associated protein 2 isoform X4
XM_039090612.2 → XP_038946540.1 calmodulin-regulated spectrin-associated protein 2 isoform X3

UniProtKB/TrEMBL

A0A8I6A5G7

Conserved Domains (4) summary

PHA03247
Location:915 → 1028

PHA03247; large tegument protein UL36; Provisional

pfam11971
Location:237 → 315

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:737 → 787

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

cl07883
Location:1340 → 1400

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
XM_039090609.2 → XP_038946537.1 calmodulin-regulated spectrin-associated protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A5G7

Related

ENSRNOP00000057155.3, ENSRNOT00000060410.6

Conserved Domains (4) summary

PHA03247
Location:915 → 1028

PHA03247; large tegument protein UL36; Provisional

pfam11971
Location:237 → 315

CAMSAP_CH; CAMSAP CH domain

pfam08683
Location:1340 → 1458

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam17095
Location:737 → 787

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin