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    Syne1 spectrin repeat containing nuclear envelope protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499010, updated on 27-Nov-2024

    Summary

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    Symbol
    Syne1provided by RGD
    Full Name
    spectrin repeat containing nuclear envelope protein 1provided by RGD
    Primary source
    RGD:620546
    See related
    EnsemblRapid:ENSRNOG00000018960 AllianceGenome:RGD:620546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CPG2; Myne-1
    Summary
    Enables enzyme binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of mesenchymal cell apoptotic process; negative regulation of mini excitatory postsynaptic potential; and regulation of receptor-mediated endocytosis. Located in several cellular components, including dendritic spine head; midbody; and nuclear membrane. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 659.2), Lung (RPKM 334.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Syne1 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    150
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43917640..44388802, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (41512146..41983382, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (41844840..42086662, complement) , (41608287..41763591, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene estrogen receptor 1 Neighboring gene uncharacterized LOC134482628 Neighboring gene small nucleolar RNA SNORD88 Neighboring gene uncharacterized LOC134482627 Neighboring gene uncharacterized LOC134482626 Neighboring gene RNA, U6 small nuclear 959 Neighboring gene myc target 1 Neighboring gene vasoactive intestinal peptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A set of genes expressed in response to light in the adult cerebral cortex and regulated during development. Nedivi E, et al. Proc Natl Acad Sci U S A, 1996 Mar 5. PMID 8700883, Free PMC Article
    2. The spectrin family member Syne-1 functions in retrograde transport from Golgi to ER. Gough LL, et al. Biochim Biophys Acta, 2004 Jul 23. PMID 15276322
    3. Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro. Yang W, et al. Mol Med Rep, 2015 Jan. PMID 25339194, Free PMC Article
    4. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Loebrich S, et al. Proc Natl Acad Sci U S A, 2013 Nov 19. PMID 24191017, Free PMC Article
    5. Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells. Yang W, et al. Int J Mol Med, 2013 Oct. PMID 23863972

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
      Title: Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
    2. Through direct interactions with F-actin and EndoB2, CPG2 physically bridges the spine cytoskeleton and the endocytic machinery, and this tripartite association is critical specifically for activity-dependent clathrin-mediated endocytosis of synaptic glutamate receptors.
      Title: CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors.
    3. the expression of nesprin-1 protein was higher during the differentiation process of MSCs and may have an important role in mediating MSC differentiation.
      Title: Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro.
    4. In the process of mesenchymal stem cell proliferation and differentiation, the upregulation of the protein expression of nesprin-1 may maintain the stability of the cell nuclear membrane and reduce the apoptosis of the mesenchymal stem cells.
      Title: Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells.
    5. CPG2 regulates synaptic AMPAR endocytosis through its association with the spine cytoskeleton and functions as a nexus for integrating PKA signaling with this process.
      Title: Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.
    6. Through the direct binding of the nesprin-1alpha amino-terminal dimerization domain to the third mAKAP spectrin repeat, nesprin-1alpha targets mAKAP to the nuclear envelope.
      Title: Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope.
    7. CPG2 is a key component of a specialized postsynaptic endocytic mechanism devoted to the internalization of synaptic proteins, including glutamate receptors.
      Title: CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors.
    8. role for in facilitating retrograde vesicular trafficking from the Golgi to the ER
      Title: The spectrin family member Syne-1 functions in retrograde transport from Golgi to ER.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytoskeleton-nuclear membrane anchor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mesenchymal cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mini excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear matrix anchoring at nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic spine head IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of meiotic nuclear membrane microtubule tethering complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic endocytic zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic endocytic zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nesprin-1
    Names
    nesprin-1-like
    spectrin repeat containing, nuclear envelope 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419849.1 → NP_001406778.1  nesprin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000099293.1, ENSRNOT00000131353.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      43917640..44388802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270573.1 → XP_063126643.1  nesprin-1 isoform X9

    2. XM_063270583.1 → XP_063126653.1  nesprin-1 isoform X12

    3. XM_063270581.1 → XP_063126651.1  nesprin-1 isoform X12

    4. XM_063270574.1 → XP_063126644.1  nesprin-1 isoform X10

      Related
      ENSRNOP00000101560.1, ENSRNOT00000143692.1

    5. XM_039101500.2 → XP_038957428.1  nesprin-1 isoform X9

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1151 → 1585
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1404 → 2254
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7993 → 8203
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4951 → 5786
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4411 → 5236
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8753 → 8809
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2398 → 2603
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    6. XM_039101511.2 → XP_038957439.1  nesprin-1 isoform X29

      UniProtKB/TrEMBL
      A0A5P8DHK4
      Conserved Domains (9) summary
      PTZ00121
      Location:1161 → 1595
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1414 → 2264
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7951 → 8161
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4961 → 5796
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4421 → 5246
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8663 → 8719
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175 → 283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2408 → 2613
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    7. XM_039101503.2 → XP_038957431.1  nesprin-1 isoform X15

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1161 → 1595
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1414 → 2264
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7998 → 8208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4961 → 5796
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4421 → 5246
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8735 → 8791
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175 → 283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2408 → 2613
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    8. XM_039101499.2 → XP_038957427.1  nesprin-1 isoform X7

      UniProtKB/TrEMBL
      A0A5P8DHN0, A0A8I5ZJB9
      Related
      ENSRNOP00000107023.1, ENSRNOT00000137901.1
      Conserved Domains (9) summary
      PTZ00121
      Location:1161 → 1595
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1414 → 2264
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7998 → 8208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4961 → 5796
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4421 → 5246
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8758 → 8814
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175 → 283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2408 → 2613
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    9. XM_039101497.2 → XP_038957425.1  nesprin-1 isoform X5

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Related
      ENSRNOP00000076933.2, ENSRNOT00000084571.3
      Conserved Domains (9) summary
      PTZ00121
      Location:1161 → 1595
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1414 → 2264
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8003 → 8213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4961 → 5796
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4421 → 5246
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8763 → 8819
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175 → 283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2408 → 2613
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    10. XM_063270618.1 → XP_063126688.1  nesprin-1 isoform X24

    11. XM_017590500.3 → XP_017445989.2  nesprin-1 isoform X23

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Related
      ENSRNOP00000104038.1, ENSRNOT00000138697.1
      Conserved Domains (8) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8010 → 8220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    12. XM_039101509.2 → XP_038957437.1  nesprin-1 isoform X21

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (8) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8010 → 8220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    13. XM_039101506.2 → XP_038957434.1  nesprin-1 isoform X19

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7958 → 8168
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4916 → 5751
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4376 → 5201
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8718 → 8774
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    14. XM_039101510.2 → XP_038957438.1  nesprin-1 isoform X22

      UniProtKB/TrEMBL
      A0A5P8DHK4
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7958 → 8168
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8670 → 8726
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    15. XM_063270600.1 → XP_063126670.1  nesprin-1 isoform X18

      Related
      ENSRNOP00000089915.2, ENSRNOT00000081637.3

    16. XM_039101504.2 → XP_038957432.1  nesprin-1 isoform X16

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7963 → 8173
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8723 → 8779
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    17. XM_039101496.2 → XP_038957424.1  nesprin-1 isoform X4

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8005 → 8215
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8765 → 8821
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    18. XM_039101495.2 → XP_038957423.1  nesprin-1 isoform X3

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8006 → 8216
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8766 → 8822
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    19. XM_039101494.2 → XP_038957422.1  nesprin-1 isoform X2

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8009 → 8219
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8769 → 8825
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    20. XM_063270606.1 → XP_063126676.1  nesprin-1 isoform X20

    21. XM_039101505.2 → XP_038957433.1  nesprin-1 isoform X17

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8010 → 8220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8722 → 8778
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    22. XM_039101502.2 → XP_038957430.1  nesprin-1 isoform X11

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8010 → 8220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8747 → 8803
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    23. XM_039101493.2 → XP_038957421.1  nesprin-1 isoform X1

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8010 → 8220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8770 → 8826
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    24. XM_063270562.1 → XP_063126632.1  nesprin-1 isoform X5

    25. XM_039101492.2 → XP_038957420.1  nesprin-1 isoform X1

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1168 → 1602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1421 → 2271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8010 → 8220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4968 → 5803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4428 → 5253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8770 → 8826
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2415 → 2620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    26. XM_063270589.1 → XP_063126659.1  nesprin-1 isoform X14

    27. XM_063270568.1 → XP_063126638.1  nesprin-1 isoform X8

    28. XM_063270587.1 → XP_063126657.1  nesprin-1 isoform X13

    29. XM_039101498.2 → XP_038957426.1  nesprin-1 isoform X6

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:1159 → 1593
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:1412 → 2262
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8001 → 8211
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4959 → 5794
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:4419 → 5244
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:8761 → 8817
      KASH; Nuclear envelope localization domain
      cd21241
      Location:15 → 134
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:173 → 281
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:2406 → 2611
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    30. XM_063270623.1 → XP_063126693.1  nesprin-1 isoform X25

    31. XM_006227851.5 → XP_006227913.1  nesprin-1 isoform X26

      UniProtKB/TrEMBL
      Q8VHJ9
      Conserved Domains (4) summary
      COG1196
      Location:219 → 965
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:2222 → 2432
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:2959 → 3015
      KASH; Nuclear envelope localization domain
      cl02488
      Location:186 → 409
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    32. XM_006227852.5 → XP_006227914.1  nesprin-1 isoform X28

      UniProtKB/TrEMBL
      A0A8I6B1X1, A6KIM8
      Conserved Domains (2) summary
      cd00176
      Location:155 → 365
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:892 → 948
      KASH; Nuclear envelope localization domain

    33. XM_063270634.1 → XP_063126704.1  nesprin-1 isoform X27

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001029909.1: Suppressed sequence

      Description
      NM_001029909.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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