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    Eva1a eva-1 homolog A, regulator of programmed cell death [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500221, updated on 27-Dec-2024

    Summary

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    Symbol
    Eva1aprovided by RGD
    Full Name
    eva-1 homolog A, regulator of programmed cell deathprovided by RGD
    Primary source
    RGD:1559797
    See related
    EnsemblRapid:ENSRNOG00000007118 AllianceGenome:RGD:1559797
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam176a; Tmem166; RGD1559797
    Summary
    Predicted to act upstream of or within several processes, including TOR signaling; cardiac left ventricle morphogenesis; and connective tissue replacement. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 81.3), Liver (RPKM 66.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eva1a in Genome Data Viewer
    Location:
    4q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (116151595..116200827)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (114593773..114643011)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (112714023..112823659)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene GC-rich sequence DNA-binding factor 2 Neighboring gene mitochondrial ribosomal protein L19 Neighboring gene peroxiredoxin 6, pseudogene 2 Neighboring gene tachykinin receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats. Li L, et al. Exp Neurol, 2012 Mar. PMID 22227058
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cardiac left ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within connective tissue replacement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within energy reserve metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein eva-1 homolog A
    Names
    family with sequence similarity 176, member A
    protein FAM176A
    transmembrane protein 166

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109243.1 → NP_001102713.1  protein eva-1 homolog A

      See identical proteins and their annotated locations for NP_001102713.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A6IAH4, D4A3V0
      Related
      ENSRNOP00000009321.5, ENSRNOT00000009321.7
      Conserved Domains (1) summary
      pfam14851
      Location:20 → 159
      FAM176; FAM176 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      116151595..116200827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108150.2 → XP_038964078.1  protein eva-1 homolog A isoform X3

      Conserved Domains (1) summary
      pfam14851
      Location:1 → 98
      FAM176; FAM176 family

    2. XM_006236708.5 → XP_006236770.1  protein eva-1 homolog A isoform X1

      See identical proteins and their annotated locations for XP_006236770.1

      UniProtKB/TrEMBL
      A6IAH4, D4A3V0
      Conserved Domains (1) summary
      pfam14851
      Location:20 → 159
      FAM176; FAM176 family

    3. XM_039108149.2 → XP_038964077.1  protein eva-1 homolog A isoform X2

      Conserved Domains (1) summary
      pfam14851
      Location:3 → 126
      FAM176; FAM176 family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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